Cigarette Smoke Decreases Innate Responses of Epithelial Cells to Rhinovirus Infection

• Published in: American journal of respiratory cell and molecular biology Vol. 44; no. 1; pp. 118 - 126
• Main Authors: Eddleston, Jane, Lee, Rachel U., Doerner, Astrid M., Herschbach, Jack, Zuraw, Bruce L.
• Format: Journal Article
• Language: English
• Published: United States American Thoracic Society 01.01.2011
• Subjects: Cell Line; Chemokine CCL5 - genetics; Chemokine CCL5 - metabolism; Chemokine CXCL10 - genetics; Chemokine CXCL10 - metabolism; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Activation; Epithelial Cells - drug effects; Epithelial Cells - enzymology; Epithelial Cells - immunology; Epithelial Cells - virology; Humans; Immunity, Innate - drug effects; Interferon Regulatory Factor-3 - metabolism; Interferon-beta - genetics; Interferon-beta - metabolism; JNK Mitogen-Activated Protein Kinases - metabolism; Mitogen-Activated Protein Kinase 1 - metabolism; Mitogen-Activated Protein Kinase 3 - metabolism; Phosphorylation; Poly I-C - immunology; Respiratory Mucosa - drug effects; Respiratory Mucosa - enzymology; Respiratory Mucosa - immunology; Respiratory Mucosa - virology; Rhinovirus - genetics; Rhinovirus - growth & development; Rhinovirus - immunology; RNA, Messenger - metabolism; RNA, Viral - biosynthesis; Smoke - adverse effects; Smoking - adverse effects; STAT1 Transcription Factor - metabolism; Time Factors; Viral Load; Virus Replication

Exposure to cigarette smoke is associated with a significant increase in the risk for respiratory viral infections. The airway epithelium is the primary target for both cigarette smoke and respiratory viral infection. We investigated the effects of cigarette smoke on the response of airway epithelia...