Distribution of Cells Labelled by a Novel Somatic Stem Cell-recognizing Antibody (A3) in Pulmonary Genesis and Bleomycin induced Pulmonary Fibrosis in Rats

• Published in: Journal of comparative pathology Vol. 148; no. 4; pp. 385 - 395
• Main Authors: Hori, M., Juniantito, V., Izawa, T., Ichikawa, C., Tanaka, M., Tanaka, K., Takenaka, S., Kuwamura, M., Yamate, J.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.05.2013
• Subjects: actin; Adult Stem Cells - metabolism; Adult Stem Cells - pathology; adults; Animals; Antibodies, Monoclonal - metabolism; Bleomycin; bronchi; Bronchi - metabolism; Bronchi - pathology; cell membranes; connective tissues; cytoplasm; Disease Models, Animal; endothelial cells; Endothelial Cells - metabolism; Endothelial Cells - pathology; Endothelium, Vascular - metabolism; Endothelium, Vascular - pathology; fibrosis; fluorescent antibody technique; Lung - metabolism; Lung - pathology; lung development; microscopy; monoclonal antibodies; muscles; organogenesis; pulmonary fibrosis; Pulmonary Fibrosis - chemically induced; Pulmonary Fibrosis - metabolism; Pulmonary Fibrosis - pathology; rat; Rats; stem cell; stem cells; vimentin; rat; stem cell; lung development; pulmonary fibrosis

Stem cells play important roles in organogenesis and remodelling after tissue injury. A monoclonal antibody (A3) has been produced against rat somatic stem cells. The present study investigated the distribution of cells labelled by A3 in the lung of fetal, neonatal and adult rats, as well as in the...