Migfilin promotes migration and invasion in glioma by driving EGFR and MMP-2 signalings： A positive feedback loop regulation

• Published in: Journal of genetics and genomics Vol. 44; no. 12; pp. 557 - 565
• Main Authors: Ou, Yunwei, Wu, Qingnan, Wu, Chuanyue, Liu, Xuefeng, Song, Yongmei, Zhan, Qimin
• Format: Journal Article
• Language: English
• Published: China Elsevier Ltd 20.12.2017
• Subjects: EGFR; Glioma; Migfilin; MMP-2; Motility; Motility; Glioma; MMP-2; MMPs; PLC-γ; STAT3; Migfilin; CNS; TIMPs; EGFR; ECM

Glioma is the most common type of primary brain tumors in the central nervous system（CNS）. Migfilin occurs in human glioma and enhances cellular motility via the epidermal growth factor receptor（EGFR）pathway. However, the underlying molecular mechanism is not fully understood. In this study, we foun...