Systemic lupus erythematosus, complicated with refractory skin ulcers, treated successfully with bosentan
A 20-year-old woman was admitted to our hospital because of bilateral pretibial edema. Administration of prednisolone was started after she was diagnosed with systemic lupus erythematosus (SLE). However, skin ulcers on her extremities developed; they subsequently worsened with tapering of prednisolo...
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| Published in | Modern rheumatology Vol. 19; no. 4; pp. 447 - 451 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Japan
Springer Japan
01.08.2009
Informa Healthcare |
| Subjects | |
| Online Access | Get full text |
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| Abstract | A 20-year-old woman was admitted to our hospital because of bilateral pretibial edema. Administration of prednisolone was started after she was diagnosed with systemic lupus erythematosus (SLE). However, skin ulcers on her extremities developed; they subsequently worsened with tapering of prednisolone. She also developed pulmonary hypertension (PH). Her skin ulcers improved considerably after administration of bosentan, an endothelin receptor antagonist. Bosentan may be efficacious not only for PH but also for refractory skin ulcers. |
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| AbstractList | A 20-year-old woman was admitted to our hospital because of bilateral pretibial edema. Administration of prednisolone was started after she was diagnosed with systemic lupus erythematosus (SLE). However, skin ulcers on her extremities developed; they subsequently worsened with tapering of prednisolone. She also developed pulmonary hypertension (PH). Her skin ulcers improved considerably after administration of bosentan, an endothelin receptor antagonist. Bosentan may be efficacious not only for PH but also for refractory skin ulcers. [PUBLICATION ABSTRACT] A 20-year-old woman was admitted to our hospital because of bilateral pretibial edema. Administration of prednisolone was started after she was diagnosed with systemic lupus erythematosus (SLE). However, skin ulcers on her extremities developed; they subsequently worsened with tapering of prednisolone. She also developed pulmonary hypertension (PH). Her skin ulcers improved considerably after administration of bosentan, an endothelin receptor antagonist. Bosentan may be efficacious not only for PH but also for refractory skin ulcers. |
| Author | Suzuki, Eiji Kanno, Takashi Ohira, Hiromasa Kyozuka, Hyo Nishida, Toru |
| Author_xml | – sequence: 1 givenname: Eiji surname: Suzuki fullname: Suzuki, Eiji email: azsuzuki7583@yahoo.co.jp organization: Division of Rheumatology, Ohta-Nishinouchi Hospital – sequence: 2 givenname: Hyo surname: Kyozuka fullname: Kyozuka, Hyo organization: Division of Rheumatology, Ohta-Nishinouchi Hospital – sequence: 3 givenname: Toru surname: Nishida fullname: Nishida, Toru organization: Division of Dermatology, Ohta-Nishinouchi Hospital – sequence: 4 givenname: Takashi surname: Kanno fullname: Kanno, Takashi organization: Division of Rheumatology, Ohta-Nishinouchi Hospital – sequence: 5 givenname: Hiromasa surname: Ohira fullname: Ohira, Hiromasa organization: Department of Internal Medicine II, Fukushima Medical University School of Medicine |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/19504167$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1016_j_rce_2011_06_012 crossref_primary_10_1002_ddr_20483 crossref_primary_10_1002_art_27307 crossref_primary_10_1155_2013_230780 |
| Cites_doi | 10.1183/09031936.02.01512001 10.1002/art.10895 10.1056/NEJMra040291 10.1002/art.20676 10.1093/rheumatology/keg050 10.1378/chest.120.5.1562 10.1016/S0140-6736(08)60919-8 10.1093/rheumatology/ken001 10.1002/art.1780251101 10.1016/S0140-6736(01)06250-X 10.1056/NEJMoa012212 10.1006/pupt.1998.0126 10.1056/NEJM199306173282402 10.1002/art.1780400928 |
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| Keywords | Systemic lupus erythematosus (SLE) Bosentan Endothelin Pulmonary hypertension (PH) Skin ulcer |
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| References | Abraham, Vancheeswaran, Dashwood, Rajkumar, Pantelides, Shi-wen (CR12) 1997; 151 Hoeper (CR1) 2002; 19 Sontheimer, Lahita (CR3) 1999 Mayes (CR19) 2003; 48 Galie, Rubin, Hoeper, Jansa, Al-Hiti, Meyer (CR15) 2008; 371 Giaid, Yanagisawa, Langleben, Michel, Levy, Shennib (CR10) 1993; 328 Rubens, Ewert, Halank, Wensel, Orzechowski, Schuitheiss (CR11) 2001; 120 CR8 Richard, Gerald, Olivier, Ivan, Adaani, Victor (CR2) 2001; 358 Korn, Mayers, Matucci Cerinic, Rainisio, Pope, Hachulla (CR4) 2004; 50 Garcia de Pena-Lefebvre, Rodriguez Rubio, Valero Exposito, Carmona, Gamir, Beltran Gutierrez (CR18) 2008; 47 Humbert, Cabane (CR17) 2003; 42 Humbert, Stibon, Simonneau (CR14) 2004; 351 Rubin, Badesch, Barst, Galie, Black, Keogh (CR13) 2002; 346 Hochberg (CR6) 1997; 40 Lawrence, Lahita (CR7) 1999 Tan, Cohen, Fries, Masi, Mcshane, Rothfield (CR5) 1982; 25 MacLean (CR9) 1998; 11 Rowell, Goodfield, Champion, Burton, Burns, Breathnach (CR16) 1997 |
| References_xml | – volume: 19 start-page: 571 year: 2002 end-page: 576 ident: CR1 article-title: Pulmonary hypertension in collagen vascular disease publication-title: Eur Respir J doi: 10.1183/09031936.02.01512001 contributor: fullname: Hoeper – volume: 48 start-page: 1190 year: 2003 end-page: 1199 ident: CR19 article-title: Endothelin and endothelin receptor antagonist in systemic rheumatic disease publication-title: Arthritis Rheum doi: 10.1002/art.10895 contributor: fullname: Mayes – volume: 151 start-page: 831 year: 1997 end-page: 841 ident: CR12 article-title: Increased levels of endothelin-1 and differential endothelin type A and B receptor expression in scleroderma-associated fibrotic lung disease publication-title: Am J Pathol contributor: fullname: Shi-wen – volume: 351 start-page: 1425 year: 2004 end-page: 1436 ident: CR14 article-title: Treatment of pulmonary arterial hypertension publication-title: N Engl J Med doi: 10.1056/NEJMra040291 contributor: fullname: Simonneau – volume: 50 start-page: 3985 year: 2004 end-page: 3993 ident: CR4 article-title: Digital ulcer in systemic sclerosis: prevention by treatment with bosentan, an oral endothelin receptor antagonist publication-title: Arthritis Rheum doi: 10.1002/art.20676 contributor: fullname: Hachulla – volume: 42 start-page: 191 year: 2003 end-page: 193 ident: CR17 article-title: Successful treatment of systemic sclerosis digital ulcers and pulmonary arterial hypertension with endothelin receptor antagonist bosentan publication-title: Rheumatology doi: 10.1093/rheumatology/keg050 contributor: fullname: Cabane – volume: 120 start-page: 1562 year: 2001 end-page: 1569 ident: CR11 article-title: Big endothelin-1 and endothelin-1 plasma levels are correlated with the severity of primary pulmonary hypertension publication-title: Chest doi: 10.1378/chest.120.5.1562 contributor: fullname: Schuitheiss – volume: 371 start-page: 2093 year: 2008 end-page: 2100 ident: CR15 article-title: Treatment of mildly symptomatic pulmonary arterial hypertension with bosentan: a double-blind, randomised controlled study publication-title: Lancet doi: 10.1016/S0140-6736(08)60919-8 contributor: fullname: Meyer – start-page: 2437 year: 1997 end-page: 2575 ident: CR16 article-title: The ‘Connective tissue diseases’ publication-title: Rook/Wilkinson/Ebling textbook of dermatology contributor: fullname: Breathnach – volume: 47 start-page: 464 year: 2008 end-page: 466 ident: CR18 article-title: Long-term experience of bosentan for treating ulcers and healed ulcers in systemic sclerosis patients publication-title: Rheumatology doi: 10.1093/rheumatology/ken001 contributor: fullname: Beltran Gutierrez – volume: 25 start-page: 1271 year: 1982 end-page: 1277 ident: CR5 article-title: The 1982 revised criteria for the classification of systemic lupus erythematosus publication-title: Arthritis Rheum doi: 10.1002/art.1780251101 contributor: fullname: Rothfield – ident: CR8 – volume: 358 start-page: 1119 year: 2001 end-page: 1123 ident: CR2 article-title: Effects of the dual endothelin-receptor antagonist bosentan in patients with pulmonary hypertension: a randomised placebo-controlled study publication-title: Lancet doi: 10.1016/S0140-6736(01)06250-X contributor: fullname: Victor – volume: 346 start-page: 896 year: 2002 end-page: 903 ident: CR13 article-title: Bosentan therapy for pulmonary arterial hypertension publication-title: N Engl J Med doi: 10.1056/NEJMoa012212 contributor: fullname: Keogh – start-page: 631 year: 1999 end-page: 656 ident: CR3 article-title: Systemic lupus erythematosus and the skin publication-title: Systemic lupus erythematosus contributor: fullname: Lahita – volume: 11 start-page: 125 year: 1998 end-page: 132 ident: CR9 article-title: Endothelin-1: a mediator of pulmonary hypertension publication-title: Pulm Pharmacol Ther doi: 10.1006/pupt.1998.0126 contributor: fullname: MacLean – volume: 328 start-page: 1732 year: 1993 end-page: 1739 ident: CR10 article-title: Expression of endothelin-1 in the lung of patients with pulmonary hypertension publication-title: N Engl J Med doi: 10.1056/NEJM199306173282402 contributor: fullname: Shennib – volume: 40 start-page: 1725 year: 1997 ident: CR6 article-title: Updating the American College of rheumatology revised criteria for the classification of systemic lupus erythematosus publication-title: Arthritis Rheum doi: 10.1002/art.1780400928 contributor: fullname: Hochberg – start-page: 719 year: 1999 end-page: 731 ident: CR7 article-title: Systemic lupus erythematosus and the lung publication-title: Systemic lupus erythematosus contributor: fullname: Lahita |
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| SubjectTerms | Adult Antihypertensive Agents - therapeutic use Case Report Case studies Drug therapy Extremities - pathology Female Humans Hypertension Hypertension, Pulmonary - drug therapy Hypertension, Pulmonary - etiology Hypertension, Pulmonary - pathology Lupus Lupus Erythematosus, Systemic - complications Lupus Erythematosus, Systemic - drug therapy Lupus Erythematosus, Systemic - pathology Medicine Medicine & Public Health Orthopedics Pulmonary arteries Rheumatology Skin Skin Ulcer - drug therapy Skin Ulcer - etiology Skin Ulcer - pathology Sulfonamides - therapeutic use Treatment Outcome Ulcers |
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| Title | Systemic lupus erythematosus, complicated with refractory skin ulcers, treated successfully with bosentan |
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