PET Imaging in Animal Models of Alzheimer's Disease

The successful development and translation of PET imaging agents targeting β-amyloid plaques and hyperphosphorylated tau tangles have allowed for detection of these hallmarks of Alzheimer's disease (AD) antemortem. Amyloid and tau PET have been incorporated into the A/T/N scheme for AD characte...

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Published inFrontiers in neuroscience Vol. 16; p. 872509
Main Authors Chen, Baosheng, Marquez-Nostra, Bernadette, Belitzky, Erika, Toyonaga, Takuya, Tong, Jie, Huang, Yiyun, Cai, Zhengxin
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 24.05.2022
Subjects
Alzheimer’s disease
neurodegeneration
Neuroscience
positron emission tomography
SV2A
tau
β-amyloid (Aβ)
Alzheimer’s disease
neuroinflamamation
SV2A
neurodegeneration
tau
animal model
positron emission tomography
β-amyloid (Aβ)
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Abstract The successful development and translation of PET imaging agents targeting β-amyloid plaques and hyperphosphorylated tau tangles have allowed for detection of these hallmarks of Alzheimer's disease (AD) antemortem. Amyloid and tau PET have been incorporated into the A/T/N scheme for AD characterization and have become an integral part of ongoing clinical trials to screen patients for enrollment, prove drug action mechanisms, and monitor therapeutic effects. Meanwhile, preclinical PET imaging in animal models of AD can provide supportive information for mechanistic studies. With the recent advancement of gene editing technologies and AD animal model development, preclinical PET imaging in AD models will further facilitate our understanding of AD pathogenesis/progression and the development of novel treatments. In this study, we review the current state-of-the-art in preclinical PET imaging using animal models of AD and suggest future research directions.
AbstractList The successful development and translation of PET imaging agents targeting β-amyloid plaques and hyperphosphorylated tau tangles have allowed for detection of these hallmarks of Alzheimer's disease (AD) antemortem. Amyloid and tau PET have been incorporated into the A/T/N scheme for AD characterization and have become an integral part of ongoing clinical trials to screen patients for enrollment, prove drug action mechanisms, and monitor therapeutic effects. Meanwhile, preclinical PET imaging in animal models of AD can provide supportive information for mechanistic studies. With the recent advancement of gene editing technologies and AD animal model development, preclinical PET imaging in AD models will further facilitate our understanding of AD pathogenesis/progression and the development of novel treatments. In this study, we review the current state-of-the-art in preclinical PET imaging using animal models of AD and suggest future research directions.
The successful development and translation of PET imaging agents targeting β-amyloid plaques and hyperphosphorylated tau tangles have allowed for in vivo detection of these hallmarks of Alzheimer’s disease (AD) antemortem. Amyloid and tau PET have been incorporated into the A/T/N scheme for AD characterization and have become an integral part of ongoing clinical trials to screen patients for enrollment, prove drug action mechanisms, and monitor therapeutic effects. Meanwhile, preclinical PET imaging in animal models of AD can provide supportive information for mechanistic studies. With the recent advancement of gene editing technologies and AD animal model development, preclinical PET imaging in AD models will further facilitate our understanding of AD pathogenesis/progression and the development of novel treatments. In this study, we review the current state-of-the-art in preclinical PET imaging using animal models of AD and suggest future research directions.
The successful development and translation of PET imaging agents targeting β-amyloid plaques and hyperphosphorylated tau tangles have allowed for in vivo detection of these hallmarks of Alzheimer’s disease (AD) antemortem. Amyloid and tau PET have been incorporated into the A/T/N scheme for AD characterization and have become an integral part of ongoing clinical trials to screen patients for enrollment, prove drug action mechanisms, and monitor therapeutic effects. Meanwhile, preclinical PET imaging in animal models of AD can provide supportive information for mechanistic studies. With the recent advancement of gene editing technologies and AD animal model development, preclinical PET imaging in AD models will further facilitate our understanding of AD pathogenesis/progression and the development of novel treatments. In this study, we review the current state-of-the-art in preclinical PET imaging using animal models of AD and suggest future research directions.
Author Chen, Baosheng
Cai, Zhengxin
Belitzky, Erika
Huang, Yiyun
Marquez-Nostra, Bernadette
Toyonaga, Takuya
Tong, Jie
AuthorAffiliation PET Center, Radiology, Yale School of Medicine , New Haven, CT , United States
AuthorAffiliation_xml – name: PET Center, Radiology, Yale School of Medicine , New Haven, CT , United States
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  givenname: Baosheng
  surname: Chen
  fullname: Chen, Baosheng
  organization: PET Center, Radiology, Yale School of Medicine, New Haven, CT, United States
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  givenname: Bernadette
  surname: Marquez-Nostra
  fullname: Marquez-Nostra, Bernadette
  organization: PET Center, Radiology, Yale School of Medicine, New Haven, CT, United States
– sequence: 3
  givenname: Erika
  surname: Belitzky
  fullname: Belitzky, Erika
  organization: PET Center, Radiology, Yale School of Medicine, New Haven, CT, United States
– sequence: 4
  givenname: Takuya
  surname: Toyonaga
  fullname: Toyonaga, Takuya
  organization: PET Center, Radiology, Yale School of Medicine, New Haven, CT, United States
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  givenname: Jie
  surname: Tong
  fullname: Tong, Jie
  organization: PET Center, Radiology, Yale School of Medicine, New Haven, CT, United States
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  givenname: Yiyun
  surname: Huang
  fullname: Huang, Yiyun
  organization: PET Center, Radiology, Yale School of Medicine, New Haven, CT, United States
– sequence: 7
  givenname: Zhengxin
  surname: Cai
  fullname: Cai, Zhengxin
  organization: PET Center, Radiology, Yale School of Medicine, New Haven, CT, United States
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Keywords Alzheimer’s disease
neuroinflamamation
SV2A
neurodegeneration
tau
animal model
positron emission tomography
β-amyloid (Aβ)
Language English
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This article was submitted to Neurodegeneration, a section of the journal Frontiers in Neuroscience
Edited by: Ruiqing Ni, ETH Zürich, Switzerland
Reviewed by: Nicolas Tournier, Commissariat à l’Energie Atomique et aux Energies Alternatives (CEA), France; Steven Liang, Massachusetts General Hospital and Harvard Medical School, United States
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Snippet The successful development and translation of PET imaging agents targeting β-amyloid plaques and hyperphosphorylated tau tangles have allowed for detection of...
The successful development and translation of PET imaging agents targeting β-amyloid plaques and hyperphosphorylated tau tangles have allowed for in vivo...
The successful development and translation of PET imaging agents targeting β-amyloid plaques and hyperphosphorylated tau tangles have allowed for in vivo...
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StartPage 872509
SubjectTerms Alzheimer’s disease
neurodegeneration
Neuroscience
positron emission tomography
SV2A
tau
β-amyloid (Aβ)
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Title PET Imaging in Animal Models of Alzheimer's Disease
URI https://www.ncbi.nlm.nih.gov/pubmed/35685772
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