Oxidative stress: role of physical exercise and antioxidant nutraceuticals in adulthood and aging

Physical exercise is considered to be one of the beneficial factors of a proper lifestyle and is nowadays seen as an indispensable element for good health, able to lower the risk of disorders of the cardiovascular, endocrine and osteomuscular apparatus, immune system diseases and the onset of potent...

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Published inOncotarget Vol. 9; no. 24; pp. 17181 - 17198
Main Authors Simioni, Carolina, Zauli, Giorgio, Martelli, Alberto M, Vitale, Marco, Sacchetti, Gianni, Gonelli, Arianna, Neri, Luca M
Format Journal Article
LanguageEnglish
Published United States Impact Journals LLC 30.03.2018
Subjects
Review
antioxidant supplementation
aging
flavonoids intake
nutraceuticals
exercise training
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Abstract Physical exercise is considered to be one of the beneficial factors of a proper lifestyle and is nowadays seen as an indispensable element for good health, able to lower the risk of disorders of the cardiovascular, endocrine and osteomuscular apparatus, immune system diseases and the onset of potential neoplasms. A moderate and programmed physical exercise has often been reported to be therapeutic both in the adulthood and in aging, since capable to promote fitness. Regular exercise alleviates the negative effects caused by free radicals and offers many health benefits, including reduced risk of all-cause mortality, sarcopenia in the skeletal muscle, chronic disease, and premature death in elderly people. However, physical performance is also known to induce oxidative stress, inflammation, and muscle fatigue. Many efforts have been carried out to identify micronutrients and natural compounds, also known as nutraceuticals, able to prevent or attenuate the exercise-induced oxidative stress and inflammation. The aim of this review is to discuss the benefits deriving from a constant physical activity and by the intake of antioxidant compounds to protect the body from oxidative stress. The attention will be focused mainly on three natural antioxidants, which are quercetin, resveratrol and curcumin. Their properties and activity will be described, as well as their benefits on physical activity and on aging, which is expected to increase through the years and can get favorable benefits from a constant exercise activity.
AbstractList Physical exercise is considered to be one of the beneficial factors of a proper lifestyle and is nowadays seen as an indispensable element for good health, able to lower the risk of disorders of the cardiovascular, endocrine and osteomuscular apparatus, immune system diseases and the onset of potential neoplasms. A moderate and programmed physical exercise has often been reported to be therapeutic both in the adulthood and in aging, since capable to promote fitness. Regular exercise alleviates the negative effects caused by free radicals and offers many health benefits, including reduced risk of all-cause mortality, sarcopenia in the skeletal muscle, chronic disease, and premature death in elderly people. However, physical performance is also known to induce oxidative stress, inflammation, and muscle fatigue. Many efforts have been carried out to identify micronutrients and natural compounds, also known as nutraceuticals, able to prevent or attenuate the exercise-induced oxidative stress and inflammation. The aim of this review is to discuss the benefits deriving from a constant physical activity and by the intake of antioxidant compounds to protect the body from oxidative stress. The attention will be focused mainly on three natural antioxidants, which are quercetin, resveratrol and curcumin. Their properties and activity will be described, as well as their benefits on physical activity and on aging, which is expected to increase through the years and can get favorable benefits from a constant exercise activity.
Physical exercise is considered to be one of the beneficial factors of a proper lifestyle and is nowadays seen as an indispensable element for good health, able to lower the risk of disorders of the cardiovascular, endocrine and osteomuscular apparatus, immune system diseases and the onset of potential neoplasms. A moderate and programmed physical exercise has often been reported to be therapeutic both in the adulthood and in aging, since capable to promote fitness. Regular exercise alleviates the negative effects caused by free radicals and offers many health benefits, including reduced risk of all-cause mortality, sarcopenia in the skeletal muscle, chronic disease, and premature death in elderly people. However, physical performance is also known to induce oxidative stress, inflammation, and muscle fatigue. Many efforts have been carried out to identify micronutrients and natural compounds, also known as nutraceuticals, able to prevent or attenuate the exercise-induced oxidative stress and inflammation. The aim of this review is to discuss the benefits deriving from a constant physical activity and by the intake of antioxidant compounds to protect the body from oxidative stress. The attention will be focused mainly on three natural antioxidants, which are quercetin, resveratrol and curcumin. Their properties and activity will be described, as well as their benefits on physical activity and on aging, which is expected to increase through the years and can get favorable benefits from a constant exercise activity.
Author Zauli, Giorgio
Martelli, Alberto M
Sacchetti, Gianni
Gonelli, Arianna
Simioni, Carolina
Neri, Luca M
Vitale, Marco
AuthorAffiliation 3 Department of Medicine and Surgery, University of Parma, Parma, Italy
1 Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy
5 Department of Life Sciences and Biotechnology, Pharmaceutical Biology Laboratory, University of Ferrara, Ferrara, Italy
2 Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy
4 CoreLab, Azienda Ospedaliero-Universitaria di Parma, Parma, Italy
AuthorAffiliation_xml – name: 3 Department of Medicine and Surgery, University of Parma, Parma, Italy
– name: 2 Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy
– name: 4 CoreLab, Azienda Ospedaliero-Universitaria di Parma, Parma, Italy
– name: 5 Department of Life Sciences and Biotechnology, Pharmaceutical Biology Laboratory, University of Ferrara, Ferrara, Italy
– name: 1 Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy
Author_xml – sequence: 1
  givenname: Carolina
  surname: Simioni
  fullname: Simioni, Carolina
– sequence: 2
  givenname: Giorgio
  surname: Zauli
  fullname: Zauli, Giorgio
– sequence: 3
  givenname: Alberto M
  surname: Martelli
  fullname: Martelli, Alberto M
– sequence: 4
  givenname: Marco
  surname: Vitale
  fullname: Vitale, Marco
– sequence: 5
  givenname: Gianni
  surname: Sacchetti
  fullname: Sacchetti, Gianni
– sequence: 6
  givenname: Arianna
  surname: Gonelli
  fullname: Gonelli, Arianna
– sequence: 7
  givenname: Luca M
  surname: Neri
  fullname: Neri, Luca M
BackLink https://www.ncbi.nlm.nih.gov/pubmed/29682215$$D View this record in MEDLINE/PubMed
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Keywords antioxidant supplementation
aging
flavonoids intake
nutraceuticals
exercise training
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