Candida albicans impairs macrophage function and facilitates Pseudomonas aeruginosa pneumonia in rat

• Published in: Critical care medicine Vol. 37; no. 3; p. 1062
• Main Authors: Roux, Damien, Gaudry, Stéphane, Dreyfuss, Didier, El-Benna, Jamel, de Prost, Nicolas, Denamur, Erick, Saumon, Georges, Ricard, Jean-Damien
• Format: Journal Article
• Language: English
• Published: United States 01.03.2009
• Subjects: Animals; Candida albicans - physiology; Macrophages - physiology; Male; Pneumonia, Bacterial - microbiology; Pseudomonas aeruginosa - pathogenicity; Rats; Rats, Wistar

To determine whether Candida albicans airway colonization influences Pseudomonas aeruginosa pneumonia prevalence in rats and by which mechanism. Prospective, randomized, controlled animal study. Research laboratory of a university. Male adult Wistar rats weighing 275-300 g. In vivo: P. aeruginosa pn...