Hematopoietic Stem Cell-Derived Adipocytes Modulate Adipose Tissue Cellularity, Leptin Production and Insulin Responsiveness in Female Mice

• Published in: Frontiers in endocrinology (Lausanne) Vol. 13; p. 844877
• Main Authors: Gavin, Kathleen M, Sullivan, Timothy M, Maltzahn, Joanne K, Jackman, Matthew R, Libby, Andrew E, MacLean, Paul S, Kohrt, Wendy M, Majka, Susan M, Klemm, Dwight J
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 03.06.2022
• Subjects: ablation; adipocyte; Adipocytes - metabolism; Adiponectin - genetics; Adiponectin - metabolism; Adipose Tissue - metabolism; Animals; cellularity; Diphtheria Toxin; Endocrinology; Female; Hematopoietic Stem Cells; Insulin - metabolism; insulin resistance; leptin; Leptin - metabolism; Mice; physical activity; cellularity; insulin resistance; leptin; ablation; adipocyte; physical activity

A subpopulation of adipocytes in the major adipose depots of mice is produced from hematopoietic stem cells rather than mesenchymal progenitors that are the source of conventional white and brown/beige adipocytes. To analyze the impact of hematopoietic stem cell-derived adipocytes (HSCDAs) in the ad...