Smart materials for drug delivery and cancer therapy

Until now, enormous smart materials have been engineered with endogenous stimulators such as pH, reactive oxygen species, glutathione, hypoxia and enzyme, or exogenous stimulators such as temperature, light, ultrasound, radiation, and magnetic field in drug delivery. As footstone of stimuli‐responsi...

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Published inView (Beijing, China) Vol. 2; no. 2
Main Authors Yang, Yao, Zeng, Weiwei, Huang, Ping, Zeng, Xiaowei, Mei, Lin
Format Journal Article
LanguageEnglish
Published Wiley 01.04.2021
Subjects
cancer therapy
drug delivery
exogenous triggered
smart materials
tumor microenvironment responsive
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Abstract Until now, enormous smart materials have been engineered with endogenous stimulators such as pH, reactive oxygen species, glutathione, hypoxia and enzyme, or exogenous stimulators such as temperature, light, ultrasound, radiation, and magnetic field in drug delivery. As footstone of stimuli‐responsive nanocarriers, endogenous/exogenous responsive smart materials possess many properties, such as responding ability to specific triggers, controlled drug release, long blood circulation, increased tumor accumulation, “ON‐OFF” switch activities, enhanced diagnostic accuracy, and therapeutic efficacy. Smart materials have attracted considerable attention because they provide likelihood strategy for individualized and comprehensive therapy. In this review, significant research achievements of smart materials responsive to different triggers including their synthesis and formulation mechanism, responsive mechanism, applications, multiple functions are summarized and discussed separately. We primarily focus on the studies in the past few years (2017‐2020). The current situation and remaining challenges of stimuli‐sensitive materials‐based nanocarriers for clinical translation are discussed rationally at the end. It is hope that this timely and overall review would provide some helpful information for researchers in this field. Smart Materials in Drug Delivery have attracted considerable attention for precision cancer chemotherapy as the footstone of stimuli‐responsive nanocarriers. Numerous smart materials are delicately designed with time‐/space‐controlled drug release while responsive to either endogenous or exogenous signals. Their advanced achievements range from preclinical studies to commercialized products. All the latest information has been comprehensively summarized herein.
AbstractList Abstract Until now, enormous smart materials have been engineered with endogenous stimulators such as pH, reactive oxygen species, glutathione, hypoxia and enzyme, or exogenous stimulators such as temperature, light, ultrasound, radiation, and magnetic field in drug delivery. As footstone of stimuli‐responsive nanocarriers, endogenous/exogenous responsive smart materials possess many properties, such as responding ability to specific triggers, controlled drug release, long blood circulation, increased tumor accumulation, “ON‐OFF” switch activities, enhanced diagnostic accuracy, and therapeutic efficacy. Smart materials have attracted considerable attention because they provide likelihood strategy for individualized and comprehensive therapy. In this review, significant research achievements of smart materials responsive to different triggers including their synthesis and formulation mechanism, responsive mechanism, applications, multiple functions are summarized and discussed separately. We primarily focus on the studies in the past few years (2017‐2020). The current situation and remaining challenges of stimuli‐sensitive materials‐based nanocarriers for clinical translation are discussed rationally at the end. It is hope that this timely and overall review would provide some helpful information for researchers in this field.
Until now, enormous smart materials have been engineered with endogenous stimulators such as pH, reactive oxygen species, glutathione, hypoxia and enzyme, or exogenous stimulators such as temperature, light, ultrasound, radiation, and magnetic field in drug delivery. As footstone of stimuli‐responsive nanocarriers, endogenous/exogenous responsive smart materials possess many properties, such as responding ability to specific triggers, controlled drug release, long blood circulation, increased tumor accumulation, “ON‐OFF” switch activities, enhanced diagnostic accuracy, and therapeutic efficacy. Smart materials have attracted considerable attention because they provide likelihood strategy for individualized and comprehensive therapy. In this review, significant research achievements of smart materials responsive to different triggers including their synthesis and formulation mechanism, responsive mechanism, applications, multiple functions are summarized and discussed separately. We primarily focus on the studies in the past few years (2017‐2020). The current situation and remaining challenges of stimuli‐sensitive materials‐based nanocarriers for clinical translation are discussed rationally at the end. It is hope that this timely and overall review would provide some helpful information for researchers in this field. Smart Materials in Drug Delivery have attracted considerable attention for precision cancer chemotherapy as the footstone of stimuli‐responsive nanocarriers. Numerous smart materials are delicately designed with time‐/space‐controlled drug release while responsive to either endogenous or exogenous signals. Their advanced achievements range from preclinical studies to commercialized products. All the latest information has been comprehensively summarized herein.
Until now, enormous smart materials have been engineered with endogenous stimulators such as pH, reactive oxygen species, glutathione, hypoxia and enzyme, or exogenous stimulators such as temperature, light, ultrasound, radiation, and magnetic field in drug delivery. As footstone of stimuli‐responsive nanocarriers, endogenous/exogenous responsive smart materials possess many properties, such as responding ability to specific triggers, controlled drug release, long blood circulation, increased tumor accumulation, “ON‐OFF” switch activities, enhanced diagnostic accuracy, and therapeutic efficacy. Smart materials have attracted considerable attention because they provide likelihood strategy for individualized and comprehensive therapy. In this review, significant research achievements of smart materials responsive to different triggers including their synthesis and formulation mechanism, responsive mechanism, applications, multiple functions are summarized and discussed separately. We primarily focus on the studies in the past few years (2017‐2020). The current situation and remaining challenges of stimuli‐sensitive materials‐based nanocarriers for clinical translation are discussed rationally at the end. It is hope that this timely and overall review would provide some helpful information for researchers in this field.
Author Zeng, Xiaowei
Huang, Ping
Yang, Yao
Mei, Lin
Zeng, Weiwei
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  surname: Yang
  fullname: Yang, Yao
  organization: Sun Yat‐sen University
– sequence: 2
  givenname: Weiwei
  surname: Zeng
  fullname: Zeng, Weiwei
  organization: Sun Yat‐sen University
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  givenname: Ping
  surname: Huang
  fullname: Huang, Ping
  organization: Sun Yat‐sen University
– sequence: 4
  givenname: Xiaowei
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  fullname: Zeng, Xiaowei
  email: zengxw23@mail.sysu.edu.cn
  organization: Sun Yat‐sen University
– sequence: 5
  givenname: Lin
  orcidid: 0000-0001-6503-5149
  surname: Mei
  fullname: Mei, Lin
  email: meilin7@mail.sysu.edu.cn
  organization: Chinese Academy of Medical Sciences & Peking Union Medical College
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Snippet Until now, enormous smart materials have been engineered with endogenous stimulators such as pH, reactive oxygen species, glutathione, hypoxia and enzyme, or...
Abstract Until now, enormous smart materials have been engineered with endogenous stimulators such as pH, reactive oxygen species, glutathione, hypoxia and...
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SubjectTerms cancer therapy
drug delivery
exogenous triggered
smart materials
tumor microenvironment responsive
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Title Smart materials for drug delivery and cancer therapy
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