Analysis of mutations in primary and metastatic synovial sarcoma

• Published in: Oncotarget Vol. 9; no. 96; pp. 36878 - 36888
• Main Authors: Xing, Zhuo, Wei, Lei, Jiang, Xiaoling, Conroy, Jeffrey, Glenn, Sean, Bshara, Wiam, Yu, Tao, Pao, Annie, Tanaka, Shinya, Kawai, Akira, Choi, Christopher, Wang, Jianmin, Liu, Song, Morrison, Carl, Yu, Y Eugene
• Format: Journal Article
• Language: English
• Published: United States Impact Journals LLC 07.12.2018
• Subjects: Research Paper; ADAM 17; synovial sarcoma; metastasis; SS18-SSX; whole exome sequencing

Synovial sarcoma is the most common pediatric non-rhabdomyosarcoma soft tissue sarcoma and accounts for about 8-10% of all soft tissue sarcoma in childhood and adolescence. The presence of a chromosomal translocation-associated -fusion gene is causally linked to development of primary synovial sarco...