IFN-γ-Primed hUCMSCs Significantly Reduced Inflammation via the Foxp3/ROR-γt/STAT3 Signaling Pathway in an Animal Model of Multiple Sclerosis

• Published in: Frontiers in immunology Vol. 13; p. 835345
• Main Authors: Ling, Xiao, Wang, Teng, Han, Chao, Wang, Pin, Liu, Xiaoli, Zheng, Chengyun, Bi, Jianzhong, Zhou, Xiaoyan
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 01.03.2022
• Subjects: Animals; Cytokines - metabolism; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; experimental autoimmune encephalomyelitis (EAE); Forkhead Transcription Factors - metabolism; Foxp3/ROR-γt/STAT3 signaling pathway; Humans; IFN-γ-primed human umbilical cord mesenchymal stem cell (IFN-γ-hUCMSCs); Immunology; indoleamine 2,3-dioxygenease (IDO); Inflammation; Interferon-gamma - metabolism; Mice; Mice, Inbred C57BL; multiple sclerosis (MS); Multiple Sclerosis - therapy; Nuclear Receptor Subfamily 1, Group F, Member 3 - metabolism; Signal Transduction; STAT3 Transcription Factor - metabolism; Umbilical Cord; Foxp3/ROR-γt/STAT3 signaling pathway; multiple sclerosis (MS); IFN-γ-primed human umbilical cord mesenchymal stem cell (IFN-γ-hUCMSCs); indoleamine 2,3-dioxygenease (IDO); experimental autoimmune encephalomyelitis (EAE)

Our previous study showed that interferon gamma (IFN-γ) might enhance the immunosuppressive properties of mesenchymal stem cells (MSCs) by upregulating the expression of indoleamine 2,3-dioxygenease. Therefore, we treated experimental autoimmune encephalomyelitis (EAE) mice, an animal model of multi...