Haloperidol Plus Ondansetron Versus Ondansetron Alone for Prophylaxis of Postoperative Nausea and Vomiting

• Published in: Anesthesia and analgesia Vol. 106; no. 5; pp. 1410 - 1413
• Main Authors: Grecu, Loreta, Bittner, Edward A., Kher, Jay, Smith, Sarah E., Rosow, Carl E.
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD International Anesthesia Research Society 01.05.2008; Lippincott
• Subjects: Adult; Aged; Anesthesia; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Antiemetics - adverse effects; Antiemetics - therapeutic use; Biological and medical sciences; Double-Blind Method; Drug Therapy, Combination; Elective Surgical Procedures; Female; Haloperidol - adverse effects; Haloperidol - therapeutic use; Humans; Male; Medical sciences; Middle Aged; Ondansetron - adverse effects; Ondansetron - therapeutic use; Postoperative Nausea and Vomiting - prevention & control; Time Factors; Treatment Outcome; Postoperative; Neuroleptic; Psychotropic; Dopamine antagonist; Serotonin antagonist; Butyrophenone derivatives; Nausea; Haloperidol; Prevention; D2 Dopamine receptor; Vomiting; 5-HT3 Serotonine receptor; Digestive diseases; Anesthesia; Antiemetic; Comparative study; Ondansetron

Haloperidol 1 mg and ondansetron 4 mg are equally safe and effective for postoperative nausea and vomiting prophylaxis. We compared the combination to ondansetron alone in a mixed surgical population. Two-hundred and sixty-eight adults undergoing general anesthesia received 4 mg ondansetron plus 1 m...