Ultrastructure of myoepithelial cells as a target cell in sialoadenitis of submandibular glands of lupus-prone female NZBxNZWF1 mice

• Published in: Virchows Archiv : an international journal of pathology Vol. 453; no. 2; pp. 177 - 188
• Main Authors: Hayashi, Toshiharu, Hayashi, Hideyuki, Fujii, Taeko, Adachi, Chie, Hasegawa, Keiko
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer-Verlag 01.08.2008; Springer; Springer Nature B.V
• Subjects: Animals; Biological and medical sciences; Disease Models, Animal; Epithelial Cells - ultrastructure; Female; Investigative techniques, diagnostic techniques (general aspects); Lupus Erythematosus, Systemic - pathology; Lymphocytes; Medical sciences; Medicine; Medicine & Public Health; Mice; Mice, Inbred NZB; Microscopy, Electron; Original Article; Pathology; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques; Salivary Gland Diseases - pathology; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; Sialadenitis - pathology; Submandibular Gland - ultrastructure; Submandibular Gland Diseases - pathology; Myoepithelial cell; mouse; Sjögren’s syndrome; Target; B/WF; Sialoadenitis; Immunopathology; Animal model; Targeting; Digestive system; Stomatology; Sjögren's syndrome, Myoepithelial cell Target, Sialoadenitis; Rodentia; Submandibular gland; Salivary gland; Autoimmune disease; Sjögren syndrome; Eye disease; Vertebrata; Anatomic pathology; Mammalia; Mouse; Ultrastructure; Animal; Systemic disease; Female; Target cell; B/WF1 mouse

The changes of myoepithelial cells of sialoadenitis in submandibular glands in lupus-prone female NZB × NZWF 1 (B/WF 1 ) mice, a model for human secondary Sjögren’s syndrome (sSS), were examined ultrastructurally. Inflammatory foci consisting of mainly lymphoid cells (lymphocytes and plasma cells) i...