Effects of chronic sepsis on contractile properties of fast twitch muscle in an experimental model of critical illness neuromyopathy in the rat

• Published in: Critical care medicine Vol. 36; no. 6; p. 1855
• Main Authors: Rossignol, Benoit, Gueret, Gildas, Pennec, Jean-Pierre, Morel, Julie, Rannou, Fabrice, Giroux-Metges, Marie-Agnès, Talarmin, Hélène, Gioux, Maxime, Arvieux, Charles C
• Format: Journal Article
• Language: English
• Published: United States 01.06.2008
• Subjects: Animals; Atracurium - pharmacokinetics; Atracurium - pharmacology; Chronic Disease; Disease Models, Animal; Female; Gene Expression - physiology; Muscle Contraction - physiology; Muscle Fibers, Fast-Twitch - physiology; Muscle Strength - physiology; Muscle Weakness - genetics; Muscle Weakness - physiopathology; Polyneuropathies - genetics; Polyneuropathies - physiopathology; Rats; Rats, Wistar; Receptors, Cholinergic - genetics; RNA, Messenger - genetics; Ryanodine Receptor Calcium Release Channel - genetics; Systemic Inflammatory Response Syndrome - genetics; Systemic Inflammatory Response Syndrome - physiopathology

Critical illness polyneuromyopathy has been extensively studied in various animal models regarding electrophysiological aspects or molecular mechanisms involved in its physiopathology; however, little data are available on its main clinical feature, that is, muscular weakness. We have studied the ef...