P2Y1 Receptor Agonist Attenuates Cardiac Fibroblasts Activation Triggered by TGF-β1

• Published in: Frontiers in pharmacology Vol. 12; p. 627773
• Main Authors: Tian, Geer, Zhou, Junteng, Quan, Yue, Kong, Qihang, Wu, Wenchao, Liu, Xiaojing
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 17.02.2021
• Subjects: cardiac fibroblast activation; cardiac fibrosis; P2Y1 receptor; Pharmacology; purinergic receptors; transverse aortic constriction; P2Y1 receptor; transverse aortic constriction; purinergic receptors; cardiac fibrosis; cardiac fibroblast activation

Cardiac fibroblasts (CFs) activation is a hallmark feature of cardiac fibrosis caused by cardiac remodeling. The purinergic signaling molecules have been proven to participate in the activation of CFs. In this study, we explored the expression pattern of P2Y receptor family in the cardiac fibrosis m...