Glycogenolytic and haemodynamic responses to bovine serum albumin in isolated perfused livers from sensitized rats

• Published in: Biochemical journal Vol. 292; no. 1; pp. 253 - 259
• Main Authors: BUXTON, D. B, HALVORSEN, O, ZHOU, W, OLSON, M. S
• Format: Journal Article
• Language: English
• Published: Colchester Portland Press 15.05.1993
• Subjects: Animals; Azepines - pharmacology; Biological and medical sciences; Calcium - metabolism; Fundamental and applied biological sciences. Psychology; Glycogen - metabolism; Hemodynamics - drug effects; Ibuprofen - pharmacology; In Vitro Techniques; Indomethacin - pharmacology; Lactates - metabolism; Lactic Acid; Liver - drug effects; Liver - metabolism; Liver. Bile. Biliary tracts; Male; Perfusion; Pyruvates - metabolism; Pyruvic Acid; Rats; Rats, Sprague-Dawley; Serum Albumin, Bovine - pharmacology; Triazoles - pharmacology; Vertebrates: digestive system; Bovine; Rat; Digestive system; Liver; Rodentia; Vasoconstriction; Animal origin; Serum albumin; Isolated organ; Proteins; Vertebrata; Mammalia; Perfusion; Animal; Glycogenolysis; Sensitization; Artiodactyla; Ungulata

Infusion of BSA into isolated perfused livers of rats sensitized by intraperitoneal injection of BSA led to rapid increases in portal-vein pressure, glucose output and the lactate/pyruvate ratio in the effluent perfusate, with concomitant decreases in oxygen consumption and lactate+pyruvate efflux....