CCR4 and CCR5 Involvement in Monocyte-Derived Macrophage Migration in Neuroinflammation

• Published in: Frontiers in immunology Vol. 13; p. 876033
• Main Authors: Kim, Jong Youl, Kim, Jiwon, Huang, Meiying, Kosonen, Renée, Lee, Jong Eun
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 12.05.2022
• Subjects: Animals; CCR4; CCR5; Chemokines - metabolism; Disease Models, Animal; Immunology; Lipopolysaccharides; Macrophages - metabolism; microglia; monocyte-derived macrophage; neuroinflammation; Neuroinflammatory Diseases; Stroke; monocyte-derived macrophage; CCR5; neuroinflammation; CCR4; microglia

Microglia, resident macrophages in the brain, play major roles in neuroinflammation after an acute many neurological diseases, including stroke. Our recent animal stroke model showed that interleukin (IL)-4 and IL-13 released by microglia are converted into monocyte-derived macrophages. However, the...