Therapeutic Drug Monitoring of Olanzapine and Cytochrome P450 Genotyping in Nonsmoking Subjects

• Published in: Therapeutic drug monitoring Vol. 42; no. 2; p. 325
• Main Authors: Miroshnichenko, Igor I, Pozhidaev, Ivan V, Ivanova, Svetlana A, Baymeeva, Natalia V
• Format: Journal Article
• Language: English
• Published: United States 01.04.2020
• Subjects: Adult; Antipsychotic Agents - pharmacokinetics; Antipsychotic Agents - therapeutic use; Chromatography, Liquid; Cytochrome P-450 CYP2D6 - genetics; Cytochrome P-450 CYP2D6 - metabolism; Drug Monitoring - methods; Genotype; Humans; Male; Non-Smokers; Olanzapine - pharmacokinetics; Olanzapine - therapeutic use; Prospective Studies; Psychotic Disorders - drug therapy; Real-Time Polymerase Chain Reaction; Schizophrenia - drug therapy; Tandem Mass Spectrometry; Young Adult

The relationship between a daily dose of olanzapine, its serum concentration, and the genotype of young nonsmoking men treated for schizophrenia or schizophreniform disorder was investigated in day-to-day clinical practice. Pharmacogenetics was also examined for the selected patients. A total of 49...