Biologics and Non-Biologics Immunosuppressive Treatments for IgA Nephropathy in Both Adults and Children

• Published in: Journal of clinical medicine Vol. 13; no. 9; p. 2465
• Main Authors: Chiarenza, Decimo Silvio, Verrina, Enrico Eugenio, La Porta, Edoardo, Caridi, Gianluca, Ghiggeri, Gian Marco, Mortari, Gabriele, Lugani, Francesca, Angeletti, Andrea, Bigatti, Carolina
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.05.2024
• Subjects: Adults; Biological products; Biopsy; Care and treatment; Demographic aspects; Diagnosis; Dosage and administration; Hypotheses; IgA glomerulonephritis; Immunosuppressive agents; Kidney diseases; Kidney transplants; Pathogenesis; Pediatrics; Safety and security measures; Steroids; Testing; Italy; BAFF; IgA nephropathy; biologics; iptacopan; BAFF/APRIL inhibitors; paediatric nephrology; complement cascade; rituximab; sibeprenlimab; APRIL

Immunoglobulin A nephropathy represents the most prevalent cause of glomerulonephritis worldwide and may lead to renal failure in a relevant number of cases in both paediatric and adult subjects. Although their pathogenesis is still largely unclear, evidence of immune abnormalities provides the back...