Targeting elevated left ventricular end-diastolic pressure following primary percutaneous coronary intervention for ST-segment elevation myocardial infarction – a phase one safety and feasibility study

• Published in: European heart journal. Acute cardiovascular care Vol. 9; no. 7; pp. 758 - 763
• Main Authors: Khan, Arshad A, Davies, Allan J, Whitehead, Nicholas J, McGee, Michael, Al-Omary, Mohammed S, Baker, David, Bhagwandeen, Rohan, Renner, Ian, Majeed, Tazeen, Hatton, Rachael, Collins, Nicholas J, Attia, John, Boyle, Andrew J
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.10.2020
• Subjects: Aged; Diastole; Feasibility Studies; Female; Follow-Up Studies; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Pilot Projects; Prognosis; Prospective Studies; Risk Factors; ST Elevation Myocardial Infarction - diagnosis; ST Elevation Myocardial Infarction - physiopathology; ST Elevation Myocardial Infarction - surgery; Stroke Volume - physiology; Ventricular Function, Left - physiology; Ventricular Pressure - physiology; Left ventricular end diastolic pressure; nitroglycerin; ST-segment elevation myocardial infarction

Introduction: Elevated left ventricular end diastolic pressure (LVEDP) is an independent predictor of mortality and heart failure in patients with ST-segment elevation myocardial infarction (STEMI). Whether lowering elevated LVEDP improves outcomes remains unknown. Methods: This non-randomized, sing...