Role of defective ERK phosphorylation in the impaired GM-CSF-induced oxidative response of neutrophils in elderly humans - Tortorella, Cosimo; Stella, Isabella; Piazzolla, Giuseppina; Simone, Olivia; Cappiello, Valentina; Antonaci, Salvatore (Mechanisms of ageing and development, 2004)
Keywords: Aged; Ageing; Aging - metabolism; Biological and medical sciences; Blotting, Western; Cell Separation; Development. Metamorphosis. Moult. Ageing; Enzyme Inhibitors - pharmacology; ERK1/2; Female; Flavonoids - pharmacology; Fundamental and applied biological sciences. Psychology; GM-CSF; Granulocyte-Macrophage Colony-Stimulating Factor - pharmacology; Humans; Imidazoles - pharmacology; In Vitro Techniques; Indicators and Reagents; Male; Mitogen-Activated Protein Kinases - metabolism; Neutrophils; Neutrophils - drug effects; Neutrophils - metabolism; Oxidation-Reduction; p38 Mitogen-Activated Protein Kinases - metabolism; p38MAPK; Phosphorylation; Pyridines - pharmacology; Respiratory burst; Respiratory Burst - drug effects; Superoxides - metabolism; TNF-α; Tumor Necrosis Factor-alpha - metabolism; Vertebrates: anatomy and physiology, studies on body, several organs or systems; ERK1/2; TNF-α; GM-CSF; Ageing; Neutrophils; Respiratory burst; p38MAPK; Human; Phosphorylation; Senescence; Extracellular signal-regulated protein kinase; Enzyme; Mitogen-activated protein kinase; Neutrophil; Elderly