Specificity of neomycin analogues bound to the packaging region of human immunodeficiency virus type 1 RNA

• Published in: Bioorganic & medicinal chemistry Vol. 12; no. 8; pp. 1835 - 1843
• Main Authors: McPike, Mark P, Goodisman, Jerry, Dabrowiak, James C
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 15.04.2004; Elsevier Science
• Subjects: Aminoglycosides; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antiviral agents; Base Sequence; Binding Sites; Biological and medical sciences; Circular dichroism; DNA Footprinting - methods; Footprinting; HIV-1 - genetics; HIV-1 - metabolism; HIV-RNA; Humans; Medical sciences; Models, Molecular; Molecular Sequence Data; Neomycin - analogs & derivatives; Neomycin - metabolism; Pharmacology. Drug treatments; RNA, Viral - genetics; RNA, Viral - metabolism; Virus Assembly - physiology; Footprinting; Aminoglycosides; HIV-RNA; Circular dichroism; Sequence specificity; RNA; HIV-1 virus; Acridine derivatives; Retroviridae; Guanidines; Binding site; Lentivirus; Modeling; Virus; Antibiotic; Biological fixation; Structure activity relation; Aminoglycoside; Targeted drug; Circular dichroism spectrometry; Molecular model; Neomycin; Antiviral; Human immunodeficiency virus; Paromomycin

The packaging region of HIV-1 RNA contains a number of structural features which are important in the life cycle of the virus, making this segment of RNA a potential target for new types of AIDS-directed drugs. We studied the binding of three neomycin analogues (neo-guanidino, neo-acridine, and neo-...