Bifidobacterium breve -derived indole-3-lactic acid ameliorates colitis-associated tumorigenesis by directing the differentiation of immature colonic macrophages

• Published in: Theranostics Vol. 14; no. 7; pp. 2719 - 2735
• Main Authors: Li, Yuke, Li, Qingxiang, Yuan, Ruoshui, Wang, Yifei, Guo, Chuanbin, Wang, Lin
• Format: Journal Article
• Language: English
• Published: Australia Ivyspring International Publisher 01.01.2024
• Subjects: Animals; Azoxymethane; Bifidobacterium breve - metabolism; Carcinogenesis - drug effects; Cell Differentiation - drug effects; Colitis - chemically induced; Colitis - complications; Colitis - microbiology; Colitis-Associated Neoplasms - metabolism; Colitis-Associated Neoplasms - microbiology; Colitis-Associated Neoplasms - pathology; Colon - metabolism; Colon - microbiology; Colon - pathology; Colorectal Neoplasms - metabolism; Colorectal Neoplasms - microbiology; Dextran Sulfate; Disease Models, Animal; Gastrointestinal Microbiome; Humans; Indoles - metabolism; Indoles - pharmacology; Macrophages - drug effects; Macrophages - metabolism; Male; Mice; Mice, Inbred C57BL; Probiotics - administration & dosage; Probiotics - pharmacology; Research Paper; Bifidobacterium breve; colitis-associated tumorigenesis; macrophage differentiation; indole-3-lactic acid; aryl hydrocarbon receptor

To elucidate dynamics and functions in colonic macrophage subsets, and their regulation by ( ) and its associated metabolites in the initiation of colitis-associated colorectal cancer (CAC). Azoxymethane (AOM) and dextran sodium sulfate (DSS) were used to create a CAC model. The tumor-suppressive ef...