Fat-Specific Sirt6 Ablation Sensitizes Mice to High-Fat Diet–Induced Obesity and Insulin Resistance by Inhibiting Lipolysis

• Published in: Diabetes (New York, N.Y.) Vol. 66; no. 5; pp. 1159 - 1171
• Main Authors: Kuang, Jiangying, Zhang, Yuwei, Liu, Qinhui, Shen, Jing, Pu, Shiyun, Cheng, Shihai, Chen, Lei, Li, Hong, Wu, Tong, Li, Rui, Li, Yanping, Zou, Min, Zhang, Zhiyong, Jiang, Wei, Xu, Guoheng, Qu, Aijuan, Xie, Wen, He, Jinhan
• Format: Journal Article
• Language: English
• Published: United States American Diabetes Association 01.05.2017
• Subjects: Ablation; Acetylation; Adipocytes - metabolism; Adipocytes - pathology; Adipose tissue; Adipose Tissue - metabolism; Adipose Tissue, White - metabolism; Adipose Tissue, White - pathology; Adult; Animals; Blotting, Western; Cell Enlargement; Chromatin Immunoprecipitation; Diet; Diet, High-Fat; Energy; Energy metabolism; Flow Cytometry; Forkhead Box Protein O1 - metabolism; FOXO1 protein; Glucose Tolerance Test; High fat diet; Humans; Hyperplasia; Hypertrophy; Immunoprecipitation; Inflammation; Insulin; Insulin resistance; Insulin Resistance - genetics; Lipase; Lipase - genetics; Lipase - metabolism; Lipolysis; Lipolysis - genetics; Metabolic disorders; Metabolism; Mice; Mice, Knockout; Middle Aged; NAD; Obesity; Obesity - genetics; Oils & fats; Phosphorylation; Real-Time Polymerase Chain Reaction; Rodents; Sirtuins - genetics; Transcription

Sirt6 is an NAD+-dependent deacetylase that is involved in the control of energy metabolism. However, the tissue-specific function of Sirt6 in the adipose tissue remains unknown. In this study, we showed that fat-specific Sirt6 knockout (FKO) sensitized mice to high-fat diet–induced obesity, which w...