Fat-Specific Sirt6 Ablation Sensitizes Mice to High-Fat Diet–Induced Obesity and Insulin Resistance by Inhibiting Lipolysis - Kuang, Jiangying; Zhang, Yuwei; Liu, Qinhui; Shen, Jing; Pu, Shiyun; Cheng, Shihai; Chen, Lei; Li, Hong; Wu, Tong; Li, Rui; Li, Yanping; Zou, Min; et al. (Diabetes (New York, N.Y.), 2017)
Keywords: Ablation; Acetylation; Adipocytes - metabolism; Adipocytes - pathology; Adipose tissue; Adipose Tissue - metabolism; Adipose Tissue, White - metabolism; Adipose Tissue, White - pathology; Adult; Animals; Blotting, Western; Cell Enlargement; Chromatin Immunoprecipitation; Diet; Diet, High-Fat; Energy; Energy metabolism; Flow Cytometry; Forkhead Box Protein O1 - metabolism; FOXO1 protein; Glucose Tolerance Test; High fat diet; Humans; Hyperplasia; Hypertrophy; Immunoprecipitation; Inflammation; Insulin; Insulin resistance; Insulin Resistance - genetics; Lipase; Lipase - genetics; Lipase - metabolism; Lipolysis; Lipolysis - genetics; Metabolic disorders; Metabolism; Mice; Mice, Knockout; Middle Aged; NAD; Obesity; Obesity - genetics; Oils & fats; Phosphorylation; Real-Time Polymerase Chain Reaction; Rodents; Sirtuins - genetics; Transcription