Early Life Exposure to Environmentally Relevant Levels of Endocrine Disruptors Drive Multigenerational and Transgenerational Epigenetic Changes in a Fish Model

• Published in: Frontiers in Marine Science Vol. 7
• Main Authors: Major, Kaley M., DeCourten, Bethany M., Li, Jie, Britton, Monica, Settles, Matthew L., Mehinto, Alvine C., Connon, Richard E., Brander, Susanne M.
• Format: Journal Article
• Language: English
• Published: Lausanne Frontiers Research Foundation 24.06.2020; Frontiers Media S.A
• Subjects: Biological fertilization; Bisulfite; Carcinogenesis; Colour; Contaminants; Deoxyribonucleic acid; DNA; DNA biosynthesis; DNA methylation; Ecotoxicology; Endocrine disruptors; Epigenetics; Estrogens; Ethinylestradiol; Euryhalinity; Exposure; Fertilization; Fish; Gene expression; Hatching; Heredity; Hormones; Immune response; Insecticides; Menidia beryllina; multigenerational exposure; Oestrogens; Offspring; Phenotypes; Physiology; Pigmentation; Progestin; Protein biosynthesis; Protein synthesis; Protein turnover; Pyrethroids; Receptors; Sex hormones; Steroidogenesis; transgenerational epigenetic inheritance; Trenbolone; United States > US

The inland silverside, Menidia beryllina, is a euryhaline fish and a model organism in ecotoxicology. We previously showend that exposure to picomolar (ng/L) levels of endocrine disrupting chemicals (EDCs) can cause a variety of effects in M. beryllina, from changes in gene expression to phenotypic...