Knocking out USP7 attenuates cardiac fibrosis and endothelial-to-mesenchymal transition by destabilizing SMAD3 in mice with heart failure with preserved ejection fraction - Yuan, Shuai; Wang, Zimu; Yao, Shun; Wang, Yanyan; Xie, Zhonglei; Wang, Jingfeng; Yu, Xueting; Song, Yu; Cui, Xiaotong; Zhou, Jingmin; Ge, Junbo (Theranostics, 2024)
Keywords: Animals; Disease Models, Animal; Epithelial-Mesenchymal Transition - genetics; Female; Fibrosis - metabolism; Heart Failure - genetics; Heart Failure - metabolism; Humans; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardium - metabolism; Myocardium - pathology; Research Paper; Smad3 Protein - metabolism; Stroke Volume; Ubiquitin-Specific Peptidase 7 - genetics; Ubiquitin-Specific Peptidase 7 - metabolism; Heart failure with preserved ejection fraction; Cardiac fibrosis; USP7; Endothelial-to-mesenchymal transition; Deubiquitination enzyme