Retinol-Binding Protein 4 Is Associated with Insulin Resistance and Body Fat Distribution in Nonobese Subjects without Type 2 Diabetes

• Published in: The journal of clinical endocrinology and metabolism Vol. 92; no. 5; pp. 1886 - 1890
• Main Authors: Gavi, Shai, Stuart, Louise M., Kelly, Patricia, Melendez, Mark M., Mynarcik, Dennis C., Gelato, Marie C., McNurlan, Margaret A.
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Oxford University Press 01.05.2007; Endocrine Society
• Subjects: Absorptiometry, Photon; Adipose tissue; Adipose Tissue - physiology; Adult; Aged; Aged, 80 and over; Aging - physiology; Biological and medical sciences; Blood Glucose - metabolism; Body Composition - physiology; Body fat; Body Mass Index; Cross-Sectional Studies; Diabetes; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - pathology; Diabetes Mellitus, Type 2 - physiopathology; Diabetes. Impaired glucose tolerance; Diagnosis; Dual energy X-ray absorptiometry; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Female; Fundamental and applied biological sciences. Psychology; Humans; Insulin resistance; Insulin Resistance - physiology; Male; Medical sciences; Middle Aged; Retinol-binding protein; Retinol-Binding Proteins - physiology; Retinol-Binding Proteins, Plasma; Vertebrates: endocrinology; Vitamin A; Waist-Hip Ratio; Endocrinopathy; Type 2 diabetes; Human; Pancreatic hormone; Adipose tissue; Metabolic diseases; Adipokine; Retinol binding protein 4; Insulin; Target tissue resistance; Distribution; Insulin resistance; Endocrinology
• ISSN: 0021-972X; 1945-7197
• DOI: 10.1210/jc.2006-1815

Background: Adipose tissue is responsible for releasing various adipokines that have been related to insulin resistance. Understanding the relationship of these adipokines to insulin resistance may foster the development of new treatments for diabetes. Objectives: The primary objective of this study...