Design, Synthesis, Molecular Docking Analysis and Biological Evaluations of 4-[(Quinolin-4-yl)amino]benzamide Derivatives as Novel Anti-Influenza Virus Agents

• Published in: International journal of molecular sciences Vol. 23; no. 11; p. 6307
• Main Authors: Zhang, Chao, Tang, Yun-Sang, Meng, Chu-Ren, Xu, Jing, Zhang, De-Liang, Wang, Jian, Huang, Er-Fang, Shaw, Pang-Chui, Hu, Chun
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 04.06.2022; MDPI
• Subjects: Acids; Avian flu; Cytotoxicity; Drug resistance; Genomes; Hydrocarbons; Pharmaceutical industry; Proteins; RNA polymerase; Viral infections; Viruses; 4-[(quinolin-4-yl)amino]benzamide derivatives; pharmacophore; RNA-dependent RNA polymerase; anti-influenza virus; molecular dynamics simulation

In this study, a series of 4-[(quinolin-4-yl)amino]benzamide derivatives as the novel anti-influenza agents were designed and synthesized. Cytotoxicity assay, cytopathic effect assay and plaque inhibition assay were performed to evaluate the anti-influenza virus A/WSN/33 (H1N1) activity of the targe...