Preconditioning and postconditioning: United at reperfusion

• Published in: Pharmacology & therapeutics (Oxford) Vol. 116; no. 2; pp. 173 - 191
• Main Authors: Hausenloy, Derek J., Yellon, Derek M.
• Format: Journal Article
• Language: English
• Published: England 01.11.2007
• Subjects: Coronary Disease - mortality; Coronary Disease - physiopathology; Coronary Disease - therapy; Drug Delivery Systems; Humans; Ischemic Preconditioning, Myocardial; Mitochondrial Membrane Transport Proteins - metabolism; Myocardial Reperfusion Injury; Protein Kinases - metabolism; Signal Transduction

Despite current optimal treatment, the morbidity and mortality of coronary heart disease (CHD), the leading cause of death worldwide, remains significant, paving the way for the development of novel cardioprotective therapies. Two potential strategies for protecting the heart are ischemic preconditi...