Neutrophil-Extracellular Traps, Cell-Free DNA, and Immunothrombosis in Companion Animals: A Review

• Published in: Veterinary Pathology Vol. 57; no. 1; pp. 6 - 23
• Main Authors: Goggs, Robert, Jeffery, Unity, LeVine, Dana N., Li, Ronald H. L.
• Format: Book Review Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 01.01.2020
• Subjects: Anemia, Hemolytic - immunology; Anemia, Hemolytic - pathology; Anemia, Hemolytic - veterinary; Animals; Blood Coagulation Disorders - immunology; Blood Coagulation Disorders - pathology; Blood Coagulation Disorders - veterinary; Cats; Cell-Free Nucleic Acids; Dogs; Extracellular Traps - immunology; Flow Cytometry - veterinary; Horses; Immunity, Innate; Neutrophils - immunology; Pets; Sepsis - immunology; Sepsis - pathology; Sepsis - veterinary; Thrombosis - immunology; Thrombosis - pathology; Thrombosis - veterinary; blood coagulation disorders; heparin; NETs; cats; neutrophil extracellular traps; thrombosis; immune-mediated hemolytic anemia; review; dogs; sepsis; horses

Immunothrombosis is a potentially beneficial physiological process that aids innate immunity and host defense against pathogen invasion. However, this process can also be damaging when it occurs to excess or in critical blood vessels. Formation of extracellular traps by leukocytes, particularly neut...