mtDNA-cGAS-STING axis-dependent NLRP3 inflammasome activation contributes to postoperative cognitive dysfunction induced by sevoflurane in mice

• Published in: International journal of biological sciences Vol. 20; no. 5; pp. 1927 - 1946
• Main Authors: Yang, Nan-Shi-Yu, Zhong, Wen-Jing, Sha, Han-Xi, Zhang, Chen-Yu, Jin, Ling, Duan, Jia-Xi, Xiong, Jian-Bing, You, Zhi-Jian, Zhou, Yong, Guan, Cha-Xiang
• Format: Journal Article
• Language: English
• Published: Australia Ivyspring International Publisher 01.01.2024
• Subjects: Research Paper; postoperative cognitive dysfunction; NLRP3 inflammasome; cGAS-STING; mitochondrial fission; neuroinflammation

The activation of NLRP3 inflammasome in microglia is critical for neuroinflammation during postoperative cognitive dysfunction (POCD) induced by sevoflurane. However, the molecular mechanism by which sevoflurane activates the NLRP3 inflammasome in microglia remains unclear. The cGAS-STING pathway is...