Randomized, multicenter trial to assess the efficacy, safety and tolerability of a single dose of a novel AMPA receptor antagonist BGG492 for the treatment of acute migraine attacks - Gomez-Mancilla, Baltazar; Brand, Ronald; Jürgens, Tim P; Göbel, Harmut; Sommer, Claudia; Straube, Andreas; Evers, Stefan; Sommer, Martin; Campos, Victor; Kalkman, Hans O; Hariry, Sam; Pezous, Nicole; et al. (Cephalalgia, 2014)
Keywords: Acute Disease; Adult; Anticonvulsants - administration & dosage; Anticonvulsants - adverse effects; Anticonvulsants - pharmacokinetics; Double-Blind Method; Female; Humans; Male; Middle Aged; Migraine Disorders - drug therapy; Placebos; Quinazolinones - administration & dosage; Quinazolinones - adverse effects; Quinazolinones - pharmacokinetics; Receptors, AMPA - antagonists & inhibitors; Serotonin 5-HT1 Receptor Agonists - administration & dosage; Serotonin 5-HT1 Receptor Agonists - adverse effects; Serotonin 5-HT1 Receptor Agonists - pharmacokinetics; Sumatriptan - administration & dosage; Sumatriptan - adverse effects; Sumatriptan - pharmacokinetics; Treatment Outcome; AMPA receptor antagonist; Migraine attack; sumatriptan