Pirfenidone for Diabetic Nephropathy

• Published in: Journal of the American Society of Nephrology Vol. 22; no. 6; pp. 1144 - 1151
• Main Authors: Sharma, Kumar, Ix, Joachim H., Mathew, Anna V., Cho, Monique, Pflueger, Axel, Dunn, Stephen R., Francos, Barbara, Sharma, Shoba, Falkner, Bonita, McGowan, Tracy A., Donohue, Michael, RamachandraRao, Satish, Xu, Ronghui, Fervenza, Fernando C., Kopp, Jeffrey B.
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society of Nephrology 01.06.2011
• Subjects: Adult; Aged; Albuminuria - urine; Anti-Inflammatory Agents, Non-Steroidal - pharmacology; Anti-Inflammatory Agents, Non-Steroidal - therapeutic use; Associated diseases and complications; Biological and medical sciences; Biomarkers - urine; Clinical Research; Creatinine - urine; Diabetes. Impaired glucose tolerance; Diabetic Nephropathies - drug therapy; Diabetic Nephropathies - metabolism; Diabetic Nephropathies - physiopathology; Disease Progression; Dose-Response Relationship, Drug; Double-Blind Method; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Female; Fibrosis; Glomerular Filtration Rate - drug effects; Glomerular Filtration Rate - physiology; Humans; Kidney - pathology; Kidneys; Male; Medical sciences; Middle Aged; Nephrology. Urinary tract diseases; Pyridones - pharmacology; Pyridones - therapeutic use; Treatment Outcome; Urinary system involvement in other diseases. Miscellaneous; Endocrinopathy; Kidney disease; Concomitant disease; Nephrology; Urinary system disease; Diabetes mellitus; Diabetic nephropathy; Pirfenidone; Urology

Pirfenidone is an oral antifibrotic agent that benefits diabetic nephropathy in animal models, but whether it is effective for human diabetic nephropathy is unknown. We conducted a randomized, double-blind, placebo-controlled study in 77 subjects with diabetic nephropathy who had elevated albuminuri...