Src dependency of the regulation of LTP by alternative splicing of GRIN1 exon 5

• Published in: Philosophical transactions of the Royal Society of London. Series B. Biological sciences Vol. 379; no. 1906; p. 20230236
• Main Authors: Li, Hongbin, Rajani, Vishaal, Sengar, Ameet S., Salter, Michael W.
• Format: Journal Article
• Language: English
• Published: England 29.07.2024
• Subjects: Alternative Splicing; Animals; Exons; Long-Term Potentiation; Male; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins - genetics; Nerve Tissue Proteins - metabolism; Receptors, N-Methyl-D-Aspartate - genetics; Receptors, N-Methyl-D-Aspartate - metabolism; src-Family Kinases - genetics; src-Family Kinases - metabolism; Synapses - metabolism; Synapses - physiology; AMPA receptors; synaptic plasticity; hippocampus; NMDA receptors

Alternative splicing of Grin1 exon 5 regulates induction of long-term potentiation (LTP) at Schaffer collateral-CA1 synapses: LTP in mice lacking the GluN1 exon 5-encoded N1 cassette (GluN1a mice) is significantly increased compared with that in mice compulsorily expressing this exon (GluN1b mice)....