Generating and influencing Torsades de Pointes--like polymorphic ventricular tachycardia in isolated guinea pig hearts

• Published in: Basic research in cardiology Vol. 93; no. 4; pp. 285 - 294
• Main Authors: Gerhardy, A, Scholtysik, G, Schaad, A, Haltiner, R, Hess, T
• Format: Journal Article
• Language: English
• Published: Germany 01.08.1998
• Subjects: Animals; Cardiotonic Agents - therapeutic use; Disease Models, Animal; Female; Guinea Pigs; Heart - drug effects; Heart - physiopathology; In Vitro Techniques; Magnesium - metabolism; Male; Myocardium - metabolism; Piperazines - therapeutic use; Torsades de Pointes - physiopathology; Veratridine - therapeutic use

Torsades de Pointes (TdP) is a polymorphic ventricular arrhythmia which can degenerate into ventricular fibrillation. The most typical symptom of TdP is the ECG morphology where QRS complexes seem to rotate around the isoelectric baseline. Bradycardia and delayed repolarization are regarded as patho...