Extracellular adenosine enhances pulmonary artery vasa vasorum endothelial cell barrier function via Gi/ELMO1/Rac1/PKA-dependent signaling mechanisms

• Published in: American Journal of Physiology: Cell Physiology Vol. 319; no. 1; pp. C183 - C193
• Main Authors: Verin, Alexander D., Batori, Robert, Kovacs-Kasa, Anita, Cherian-Shaw, Mary, Kumar, Sanjiv, Czikora, Istvan, Karoor, Vijaya, Strassheim, Derek, Stenmark, Kurt R., Gerasimovskaya, Evgenia V.
• Format: Journal Article
• Language: English
• Published: Bethesda, MD American Physiological Society 01.07.2020

The vasa vasorum (VV), the microvascular network around large vessels, has been recognized as an important contributor to the pathological vascular remodeling in cardiovascular diseases. In bovine and rat models of hypoxic pulmonary hypertension (PH), we have previously shown that chronic hypoxia pr...