Increased methylglyoxal formation in plasma and tissues during a glucose tolerance test is derived from exogenous glucose

• Published in: Clinical science (1979) Vol. 137; no. 8; pp. 697 - 706
• Main Authors: Zhang, Xiaodi, Scheijen, Jean L.J.M., Stehouwer, Coen D.A., Wouters, Kristiaan, Schalkwijk, Casper G.
• Format: Journal Article
• Language: English
• Published: England Portland Press Ltd 26.04.2023
• Subjects: Animals; Diabetes & Metabolic Disorders; Diabetes Mellitus, Type 2; Glucose; Glucose Tolerance Test; Glycation End Products, Advanced; Magnesium Oxide; Male; Metabolism; Mice; Mice, Inbred C57BL; Molecular Bases of Health & Disease; Pyruvaldehyde; methylglyoxal; methylglyoxal stress; advanced glycation end products; diabetes

The dicarbonyl compound methylglyoxal (MGO) is a major precursor in the formation of advanced glycation endproducts (AGEs). MGO and AGEs are increased in subjects with diabetes and are associated with fatal and nonfatal cardiovascular disease. Previously, we have shown that plasma MGO concentrations...