Cx31.1 can selectively intermix with co-expressed connexins to facilitate its assembly into gap junctions

• Published in: Journal of cell science Vol. 137; no. 7
• Main Authors: Leighton, Stephanie E., Wong, Robert S., Lucaciu, Sergiu A., Hauser, Alexandra, Johnston, Danielle, Stathopulos, Peter B., Bai, Donglin, Penuela, Silvia, Laird, Dale W.
• Format: Journal Article
• Language: English
• Published: England The Company of Biologists Ltd 01.04.2024
• Subjects: Animals; Cell Communication - physiology; Connexin 43 - genetics; Connexin 43 - metabolism; Connexins - genetics; Connexins - metabolism; Gap Junctions - metabolism; Humans; Ion Channels - metabolism; Keratinocytes - metabolism; Mammals - metabolism; Connexin; Cx31.1; Keratinocyte; Gap junctional intercellular communication; Trafficking; Gap junction

Connexins are channel-forming proteins that function to facilitate gap junctional intercellular communication. Here, we use dual cell voltage clamp and dye transfer studies to corroborate past findings showing that Cx31.1 (encoded by GJB5) is defective in gap junction channel formation, illustrating...