Dynamics of Base Excision Repair at the Maternal–Fetal Interface in Pregnancies Complicated by Preeclampsia

• Published in: Reproductive sciences (Thousand Oaks, Calif.) Vol. 24; no. 6; pp. 856 - 864
• Main Authors: Tadesse, Serkalem, Norwitz, Nicholas G., Guller, Seth, Arcuri, Felice, Toti, Paolo, Norwitz, Errol R., Kidane, Dawit
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 01.06.2017; Springer International Publishing
• Subjects: DNA Glycosylases - genetics; DNA Glycosylases - metabolism; DNA Repair - genetics; DNA-(Apurinic or Apyrimidinic Site) Lyase - genetics; DNA-(Apurinic or Apyrimidinic Site) Lyase - metabolism; Embryology; Female; Humans; Medicine & Public Health; Obstetrics/Perinatology/Midwifery; Original Article; Oxidative Stress - genetics; Placenta - metabolism; Pre-Eclampsia - genetics; Pre-Eclampsia - metabolism; Pregnancy; Reproductive Medicine; Trophoblasts - metabolism; base excision repair; OGG1 and APE1; preeclampsia

Preeclampsia (PE) (gestational proteinuric hypertension) is the leading cause of maternal and perinatal mortality worldwide. Although placental endothelial dysfunction and oxidative stress are known to contribute to PE, the exact pathological basis for this disorder remains unclear. Previously, we d...