Reference intervals for thyroid hormones on Advia Centaur derived from three reference populations and a review of the literature

Laboratories are recommended to determine their own local reference intervals (RIs) to embrace the variations in local populations. We have assessed local RIs for thyroid function tests using two different approaches to selection of reference populations and also searched the literature for studies...

Full description

Saved in:
Bibliographic Details
Published inAnnals of clinical biochemistry Vol. 53; no. Pt 3; p. 385
Main Authors Barth, Julian H, Spencer, Jennifer D, Goodall, Stephen R, Luvai, Ahai
Format Journal Article
LanguageEnglish
Published England 01.05.2016
Subjects
Online AccessGet more information

Cover

Loading…
Abstract Laboratories are recommended to determine their own local reference intervals (RIs) to embrace the variations in local populations. We have assessed local RIs for thyroid function tests using two different approaches to selection of reference populations and also searched the literature for studies using the Advia Centaur methods. Two independent populations were made of redundant serum samples from primary care in which exclusion criteria were used to reduce the inclusion of patients with thyroid disease. A further population of healthy subjects were recruited. All groups were restricted to 18-65 years and thyroid peroxidase antibodies (TPOabs) positive subjects were excluded. All samples were analysed using Advia Centaur reagents. A literature search was made for RI studies on non-pregnant adults using Advia Centaur. Redundant data sets consisted of 219 and 222 subjects and a healthy population of 280. Comparison of variance of all three groups showed differences for free T4 (fT4) and total T3 (TT3) (analysis of variance P < 0.0001) but thyroid-stimulating hormone (TSH) was similar across all three groups (P = 0.7656). RI for TSH, fT4 and TT3 all fell within the 95% confidence interval for each other for all three analytes. Published RIs give wide variation although their mean is similar to the prospective data reported here. Our data suggest that a consensus set of RIs for Advia Centaur can be adopted from the prospective studies and literature search in this paper and we would suggest the following RIs: TSH 0.5-4.4 mIU/L; fT4 10-20 pmol/L; and TT3 1.1-2.4 nmol/L.
AbstractList Laboratories are recommended to determine their own local reference intervals (RIs) to embrace the variations in local populations. We have assessed local RIs for thyroid function tests using two different approaches to selection of reference populations and also searched the literature for studies using the Advia Centaur methods. Two independent populations were made of redundant serum samples from primary care in which exclusion criteria were used to reduce the inclusion of patients with thyroid disease. A further population of healthy subjects were recruited. All groups were restricted to 18-65 years and thyroid peroxidase antibodies (TPOabs) positive subjects were excluded. All samples were analysed using Advia Centaur reagents. A literature search was made for RI studies on non-pregnant adults using Advia Centaur. Redundant data sets consisted of 219 and 222 subjects and a healthy population of 280. Comparison of variance of all three groups showed differences for free T4 (fT4) and total T3 (TT3) (analysis of variance P < 0.0001) but thyroid-stimulating hormone (TSH) was similar across all three groups (P = 0.7656). RI for TSH, fT4 and TT3 all fell within the 95% confidence interval for each other for all three analytes. Published RIs give wide variation although their mean is similar to the prospective data reported here. Our data suggest that a consensus set of RIs for Advia Centaur can be adopted from the prospective studies and literature search in this paper and we would suggest the following RIs: TSH 0.5-4.4 mIU/L; fT4 10-20 pmol/L; and TT3 1.1-2.4 nmol/L.
Author Spencer, Jennifer D
Luvai, Ahai
Barth, Julian H
Goodall, Stephen R
Author_xml – sequence: 1
  givenname: Julian H
  surname: Barth
  fullname: Barth, Julian H
  email: julian.barth@nhs.net
  organization: Blood Sciences, Leeds General Infirmary, Leeds, UK julian.barth@nhs.net
– sequence: 2
  givenname: Jennifer D
  surname: Spencer
  fullname: Spencer, Jennifer D
  organization: Blood Sciences, Leeds General Infirmary, Leeds, UK
– sequence: 3
  givenname: Stephen R
  surname: Goodall
  fullname: Goodall, Stephen R
  organization: Blood Sciences, Leeds General Infirmary, Leeds, UK
– sequence: 4
  givenname: Ahai
  surname: Luvai
  fullname: Luvai, Ahai
  organization: Blood Sciences, Leeds General Infirmary, Leeds, UK
BackLink https://www.ncbi.nlm.nih.gov/pubmed/27048695$$D View this record in MEDLINE/PubMed
BookMark eNo9kEtLAzEUhYMo9qF7V3L_wGiSSSbpshStQkEQXZdkcodGOsmQeUiX_nMDPlZncT7OB2dBzkMMSMgNo3eMKXVPKRWyKjmrqrLSK3VG5kxJXTBK2Yws-v4jE1xReklmOYSuVnJOvl6xwYShRvBhwDSZYw9NTDAcTil6B4eY2izqIQZYu8kb2GAYzJjAYfITOmhSbDOeECH9j3WxG49m8DH0YIIDk7vJ4yfEJrMIR59lZhgTXpGLJkvx-jeX5P3x4W3zVOxets-b9a6oS7UaCulqy7WljWBMcMml00JwrazV1vJGOIXCSlcZXRq0WihEp6hSzJROSFnzJbn92e1G26Lbd8m3Jp32f1_wbxVZY7k
CitedBy_id crossref_primary_10_1177_00045632231202211
crossref_primary_10_1371_journal_pone_0261715
crossref_primary_10_3389_fendo_2023_1080330
crossref_primary_10_1080_00365513_2019_1571624
crossref_primary_10_1177_0004563217691549
crossref_primary_10_1080_10408363_2022_2121960
crossref_primary_10_1210_clinem_dgac546
crossref_primary_10_1093_jalm_jfac067
ContentType Journal Article
Copyright The Author(s) 2016.
Copyright_xml – notice: The Author(s) 2016.
DBID CGR
CUY
CVF
ECM
EIF
NPM
DOI 10.1177/0004563216636897
DatabaseName Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
DatabaseTitleList MEDLINE
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod no_fulltext_linktorsrc
Discipline Medicine
Chemistry
EISSN 1758-1001
ExternalDocumentID 27048695
Genre Journal Article
Review
GroupedDBID ---
.55
.GJ
0B8
0R~
23M
35A
36B
3V.
4.4
53G
5GY
5I-
5I.
5RE
5VS
6J9
7X7
88A
88E
88I
8AF
8AO
8CJ
8FE
8FG
8FH
8FI
8FJ
8R4
8R5
AACMV
AACTG
AAEWN
AAGMC
AAJIQ
AAJOX
AAKGS
AAQXH
AATBZ
AAUAS
AAWTL
AAXOT
AAXTJ
AAYTG
AAZBJ
ABDWY
ABHKI
ABJCF
ABJIS
ABLUO
ABPGX
ABUWG
ABVVC
ABWRX
ACFEJ
ACFIC
ACFMA
ACFYK
ACGBL
ACGFO
ACGFS
ACGOD
ACGZN
ACGZU
ACIWK
ACJOP
ACJTF
ACLFY
ACLHI
ACPRK
ACPTO
ACSBE
ACUAV
ACXMB
ADBBV
ADFPL
ADMPF
ADNBR
ADTBJ
ADWAY
AECGH
AECVZ
AEDTQ
AEKYL
AEMJX
AENEX
AEPTA
AEWDL
AEWLI
AEXFG
AFDWH
AFIEG
AFKRA
AFKRG
AFNTS
AGWFA
AHMBA
AHOKE
AI.
AIGRN
AIIQI
AIOMO
AJABX
AJEFB
AJMMQ
AJSCY
AJUZI
AJXAJ
ALIPV
ALKWR
ALMA_UNASSIGNED_HOLDINGS
ALTZF
AMCVQ
AOSDY
ARTOV
AYAKG
AZQEC
BBNVY
BBRGL
BENPR
BES
BGLVJ
BHPHI
BKIIM
BPACV
BPHCQ
BVXVI
BWJAD
CAG
CCPQU
CGR
COF
CORYS
CQQTX
CS3
CUTAK
CUY
CVF
D1I
D1J
DB0
DC.
DC0
DD-
DE-
DF0
DN0
DO-
DWQXO
EBS
ECM
EIF
EJD
EMOBN
F5P
FHBDP
FYUFA
GNUQQ
H13
HCIFZ
HMCUK
HZ~
J5H
J8X
KB.
LK8
M0L
M1P
M2P
M2Q
M4V
M7P
MV1
NPM
O9-
P.B
P.C
P2P
PDBOC
PQQKQ
PROAC
PSQYO
Q1R
Q2X
ROL
RWL
RXW
S0X
SCNPE
SFC
SHG
SPQ
SPV
TAE
TRM
UCJ
UKHRP
VH1
WH7
X6Y
X7M
ZXP
ID FETCH-LOGICAL-c379t-5dcb28b0f41142525d844287bb8bb2f4d7e4b5d6a83aeb847eed70771a3d455c2
IngestDate Tue Oct 15 23:51:30 EDT 2024
IsDoiOpenAccess false
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue Pt 3
Keywords analytes
Thyroid hormones
Language English
License The Author(s) 2016.
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-c379t-5dcb28b0f41142525d844287bb8bb2f4d7e4b5d6a83aeb847eed70771a3d455c2
OpenAccessLink https://journals.sagepub.com/doi/pdf/10.1177/0004563216636897
PMID 27048695
ParticipantIDs pubmed_primary_27048695
PublicationCentury 2000
PublicationDate 2016-05-01
PublicationDateYYYYMMDD 2016-05-01
PublicationDate_xml – month: 05
  year: 2016
  text: 2016-05-01
  day: 01
PublicationDecade 2010
PublicationPlace England
PublicationPlace_xml – name: England
PublicationTitle Annals of clinical biochemistry
PublicationTitleAlternate Ann Clin Biochem
PublicationYear 2016
SSID ssj0002700
Score 2.2221396
SecondaryResourceType review_article
Snippet Laboratories are recommended to determine their own local reference intervals (RIs) to embrace the variations in local populations. We have assessed local RIs...
SourceID pubmed
SourceType Index Database
StartPage 385
SubjectTerms Adolescent
Adult
Aged
Humans
Middle Aged
Reference Values
Thyroid Hormones - analysis
Young Adult
Title Reference intervals for thyroid hormones on Advia Centaur derived from three reference populations and a review of the literature
URI https://www.ncbi.nlm.nih.gov/pubmed/27048695
Volume 53
hasFullText
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Na9wwEBWbBNpcQpN-Jf1gDr0Fp2tLtuzjEtqG0oRAE8gtSJZNDO16WXYDyS2_Kn8vM5ZsiU1LPy5msXZt43lonzRv3jD2QZCxk-Y8GhdGRsLEOipKpSIi8zo2JlcxFTgfn2RH5-LrRXoxGt0HqqXlQh-Ut7-sK_mfqOI5jCtVyf5DZIeL4gn8jPHFI0YYj38VY-8S23TSRbJCtrLBm3nbmP0rJKTkxU8ZgYm5blS3mauW1BR8jtOc6atL5hV1T-kvNhuaelkDZxUUuBBP_TFYMYfU1lsxD9WWuqF-XLahnN8ydZpEqszGyWVIVX2f0c3noeTGy5G_tK1RNkPidGle6fhteW17ak-uVBPuYsSZ1wweVHbmxYVLRIZQ4dRsfYQdBE8X-zyYarlt9fP4L6BLQluuypMYGVWWWwlwgIjZzw4SiSTHwSL98-iKKXc_tMbWZE4dQ05ok8gRAMrl-4z4x9VHIf9p9_OVtUzHac6esS23GIGJRdY2G1XTHfb0sA_ZDnty7KQXz9ndADYYwAYINnBggx5s0E6hAxs4sIEDGxDYoAMbDGCDAGyAYAMFFmzQ1vjdCjzYXrDzz5_ODo8i178jKrksFlFqSp3kelwLKthOk9TkglboWudaJ7UwshI6NZnKuao00iTka3IsZay4EWlaJi_Z-hQf_DUDTrZ8gtQSRSzqrCjyWskqi7OyrPVY8132yr7Iy5k1abnsX_Heb0fesE2PxLdso8b3Vr1DirnQ77uAPgAO-IAI
link.rule.ids 780
linkProvider National Library of Medicine
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Reference+intervals+for+thyroid+hormones+on+Advia+Centaur+derived+from+three+reference+populations+and+a+review+of+the+literature&rft.jtitle=Annals+of+clinical+biochemistry&rft.au=Barth%2C+Julian+H&rft.au=Spencer%2C+Jennifer+D&rft.au=Goodall%2C+Stephen+R&rft.au=Luvai%2C+Ahai&rft.date=2016-05-01&rft.eissn=1758-1001&rft.volume=53&rft.issue=Pt+3&rft.spage=385&rft_id=info:doi/10.1177%2F0004563216636897&rft_id=info%3Apmid%2F27048695&rft_id=info%3Apmid%2F27048695&rft.externalDocID=27048695