Sex, sepsis and the brain: defining the role of sexual dimorphism on neurocognitive outcomes after infection

• Published in: Clinical science (1979) Vol. 137; no. 12; p. 963
• Main Authors: Polcz, Valerie E, Barrios, Evan L, Chapin, Benjamin, Price, Catherine C, Nagpal, Ravinder, Chakrabarty, Paramita, Casadesus, Gemma, Foster, Thomas, Moldawer, Lyle L, Efron, Philip A
• Format: Journal Article
• Language: English
• Published: England 28.06.2023
• Subjects: Brain; Humans; Male; Sepsis - complications; Sepsis-Associated Encephalopathy - complications; Sex Characteristics; dementia; sepsis-associated encephalopathy; neurocognition; sepsis; sexual dimorphism; neurocognitive disease

Sexual dimorphisms exist in multiple domains, from learning and memory to neurocognitive disease, and even in the immune system. Male sex has been associated with increased susceptibility to infection, as well as increased risk of adverse outcomes. Sepsis remains a major source of morbidity and mort...