Multiple members of the TNF superfamily contribute to IFN-gamma-mediated inhibition of erythropoiesis

• Published in: The Journal of immunology (1950) Vol. 175; no. 3; pp. 1464 - 1472
• Main Authors: Felli, Nadia, Pedini, Francesca, Zeuner, Ann, Petrucci, Eleonora, Testa, Ugo, Conticello, Concetta, Biffoni, Mauro, Di Cataldo, Andrea, Winkles, Jeffrey A, Peschle, Cesare, De Maria, Ruggero
• Format: Journal Article
• Language: English
• Published: United States 01.08.2005
• Subjects: Apoptosis Regulatory Proteins; Carrier Proteins - biosynthesis; Carrier Proteins - physiology; Cell Differentiation - immunology; Cell Proliferation; Cells, Cultured; Cytokine TWEAK; Erythroblasts - cytology; Erythroblasts - immunology; Erythroblasts - metabolism; Erythropoiesis - immunology; Fas Ligand Protein; Growth Inhibitors - physiology; Humans; Immunologic Factors - biosynthesis; Immunologic Factors - physiology; Interferon-gamma - physiology; Ligands; Membrane Glycoproteins - physiology; Membrane Proteins - biosynthesis; Membrane Proteins - physiology; Receptors, Tumor Necrosis Factor - biosynthesis; Receptors, Tumor Necrosis Factor - physiology; TNF-Related Apoptosis-Inducing Ligand; Tumor Necrosis Factor-alpha - physiology; Tumor Necrosis Factors - biosynthesis; Tumor Necrosis Factors - physiology; TWEAK Receptor; Up-Regulation - immunology

IFN-gamma inhibits the growth and differentiation of erythroid precursor cells and mediates hemopoietic suppression through mechanisms that are not completely understood. We found that treatment of human erythroid precursor cells with IFN-gamma up-regulates the expression of multiple members of the...