Multi-target interphase fluorescence in situ hybridization assay increases sensitivity of sputum cytology as a predictor of lung cancer
Survival rates for lung cancer are low because patients have disseminated disease at diagnosis; therefore tests for early diagnosis are highly desirable. This pilot study investigated occurrence of chromosomal aneusomy in sputum from a 33 case-control cohort matched on age, gender, and date of sampl...
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| Published in | Cancer detection and prevention Vol. 28; no. 4; pp. 244 - 251 |
|---|---|
| Main Authors | , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Elsevier Ltd
01.01.2004
Elsevier Limited |
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| Abstract | Survival rates for lung cancer are low because patients have disseminated disease at diagnosis; therefore tests for early diagnosis are highly desirable. This pilot study investigated occurrence of chromosomal aneusomy in sputum from a 33 case-control cohort matched on age, gender, and date of sample collection. Subjects had chronic obstructive pulmonary disease and ≥30 pack-years of tobacco use, and aneusomy was tested using a multi-target DNA FISH assay (LAVysion, Abbott/Vysis). In specimens collected within 12 months of lung cancer diagnosis, abnormality was more frequent among the 18 cases (41%) than the 17 controls (6%;
P = 0.04). Aneusomy had no significant association with cytologic atypia, which might indicate that molecular and morphological changes could be independent markers of tumorigenesis. Combining both tests, abnormality was found in 83% of the cases and 20% of the controls (
P = 0.0004) suggesting that FISH may improve the sensitivity of cytologic atypia as a predictor of lung cancer. |
|---|---|
| AbstractList | Survival rates for lung cancer are low because patients have disseminated disease at diagnosis; therefore tests for early diagnosis are highly desirable. This pilot study investigated occurrence of chromosomal aneusomy in sputum from a 33 case-control cohort matched on age, gender, and date of sample collection. Subjects had chronic obstructive pulmonary disease and > or = 30 pack-years of tobacco use, and aneusomy was tested using a multi-target DNA FISH assay (LAVysion, Abbott/Vysis). In specimens collected within 12 months of lung cancer diagnosis, abnormality was more frequent among the 18 cases (41%) than the 17 controls (6%; P = 0.04). Aneusomy had no significant association with cytologic atypia, which might indicate that molecular and morphological changes could be independent markers of tumorigenesis. Combining both tests, abnormality was found in 83% of the cases and 20% of the controls (P = 0.0004) suggesting that FISH may improve the sensitivity of cytologic atypia as a predictor of lung cancer. Survival rates for lung cancer are low because patients have disseminated disease at diagnosis; therefore tests for early diagnosis are highly desirable. This pilot study investigated occurrence of chromosomal aneusomy in sputum from a 33 case-control cohort matched on age, gender, and date of sample collection. Subjects had chronic obstructive pulmonary disease and ≥30 pack-years of tobacco use, and aneusomy was tested using a multi-target DNA FISH assay (LAVysion, Abbott/Vysis). In specimens collected within 12 months of lung cancer diagnosis, abnormality was more frequent among the 18 cases (41%) than the 17 controls (6%;P= 0.04). Aneusomy had no significant association with cytologic atypia, which might indicate that molecular and morphological changes could be independent markers of tumorigenesis. Combining both tests, abnormality was found in 83% of the cases and 20% of the controls (P= 0.0004) suggesting that FISH may improve the sensitivity of cytologic atypia as a predictor of lung cancer. Survival rates for lung cancer are low because patients have disseminated disease at diagnosis; therefore tests for early diagnosis are highly desirable. This pilot study investigated occurrence of chromosomal aneusomy in sputum from a 33 case-control cohort matched on age, gender, and date of sample collection. Subjects had chronic obstructive pulmonary disease and > or = 30 pack-years of tobacco use, and aneusomy was tested using a multi-target DNA FISH assay (LAVysion, Abbott/Vysis). In specimens collected within 12 months of lung cancer diagnosis, abnormality was more frequent among the 18 cases (41%) than the 17 controls (6%; P = 0.04). Aneusomy had no significant association with cytologic atypia, which might indicate that molecular and morphological changes could be independent markers of tumorigenesis. Combining both tests, abnormality was found in 83% of the cases and 20% of the controls (P = 0.0004) suggesting that FISH may improve the sensitivity of cytologic atypia as a predictor of lung cancer. Survival rates for lung cancer are low because patients have disseminated disease at diagnosis; therefore tests for early diagnosis are highly desirable. This pilot study investigated occurrence of chromosomal aneusomy in sputum from a 33 case-control cohort matched on age, gender, and date of sample collection. Subjects had chronic obstructive pulmonary disease and ≥30 pack-years of tobacco use, and aneusomy was tested using a multi-target DNA FISH assay (LAVysion, Abbott/Vysis). In specimens collected within 12 months of lung cancer diagnosis, abnormality was more frequent among the 18 cases (41%) than the 17 controls (6%; P = 0.04). Aneusomy had no significant association with cytologic atypia, which might indicate that molecular and morphological changes could be independent markers of tumorigenesis. Combining both tests, abnormality was found in 83% of the cases and 20% of the controls ( P = 0.0004) suggesting that FISH may improve the sensitivity of cytologic atypia as a predictor of lung cancer. |
| Author | Kittelson, John Wolf, Holly J. Varella-Garcia, Marileila Zeng, Chan Byers, Tim Keith, Robert L. Franklin, Wilbur A. Hirsch, Fred R. Vu, Kieu O. Kennedy, Tim Schulte, Aline P. Miller, York E. |
| Author_xml | – sequence: 1 givenname: Marileila surname: Varella-Garcia fullname: Varella-Garcia, Marileila email: marileila.garcia@uchsc.edu organization: Department of Medicine, School of Medicine, University of Colorado Health Sciences Center, Cancer Center, Campus Box B188, Denver, CO 80262, USA – sequence: 2 givenname: John surname: Kittelson fullname: Kittelson, John organization: Department of Preventive Medicine and Biostatistics, School of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA – sequence: 3 givenname: Aline P. surname: Schulte fullname: Schulte, Aline P. organization: Department of Medicine, School of Medicine, University of Colorado Health Sciences Center, Cancer Center, Campus Box B188, Denver, CO 80262, USA – sequence: 4 givenname: Kieu O. surname: Vu fullname: Vu, Kieu O. organization: Department of Preventive Medicine and Biostatistics, School of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA – sequence: 5 givenname: Holly J. surname: Wolf fullname: Wolf, Holly J. organization: Department of Preventive Medicine and Biostatistics, School of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA – sequence: 6 givenname: Chan surname: Zeng fullname: Zeng, Chan organization: Department of Preventive Medicine and Biostatistics, School of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA – sequence: 7 givenname: Fred R. surname: Hirsch fullname: Hirsch, Fred R. organization: Department of Medicine, School of Medicine, University of Colorado Health Sciences Center, Cancer Center, Campus Box B188, Denver, CO 80262, USA – sequence: 8 givenname: Tim surname: Byers fullname: Byers, Tim organization: Department of Preventive Medicine and Biostatistics, School of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA – sequence: 9 givenname: Tim surname: Kennedy fullname: Kennedy, Tim organization: Pulmonology Division, Department of Medicine, Presbyterian/St. Lukes Health One Medical Center, Denver, CO, USA – sequence: 10 givenname: York E. surname: Miller fullname: Miller, York E. organization: Pulmonology Division, Department of Medicine, Eastern Colorado Veterans Administration Medical Center, Denver, CO, USA – sequence: 11 givenname: Robert L. surname: Keith fullname: Keith, Robert L. organization: Pulmonology Division, Department of Medicine, Eastern Colorado Veterans Administration Medical Center, Denver, CO, USA – sequence: 12 givenname: Wilbur A. surname: Franklin fullname: Franklin, Wilbur A. organization: Department of Pathology, School of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA |
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| SubjectTerms | Aged Aged, 80 and over Cancer Case-control Case-Control Studies Chromosomal Instability Chromosome Aberrations DNA methylation Epidemiology Female Humans In Situ Hybridization, Fluorescence Lung cancer Lung Neoplasms - diagnosis Lung Neoplasms - pathology Male Middle Aged Molecular cytogenetics Mortality Multicolor FISH Pulmonary Disease, Chronic Obstructive Risk Assessment Sensitivity and Specificity Smoking Sputum Studies |
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| Title | Multi-target interphase fluorescence in situ hybridization assay increases sensitivity of sputum cytology as a predictor of lung cancer |
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