Biological Potential, Gastrointestinal Digestion, Absorption, and Bioavailability of Algae-Derived Compounds with Neuroprotective Activity: A Comprehensive Review
Currently, there is no known cure for neurodegenerative disease. However, the available therapies aim to manage some of the symptoms of the disease. Human neurodegenerative diseases are a heterogeneous group of illnesses characterized by progressive loss of neuronal cells and nervous system dysfunct...
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| Published in | Marine drugs Vol. 20; no. 6; p. 362 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
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28.05.2022
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| Abstract | Currently, there is no known cure for neurodegenerative disease. However, the available therapies aim to manage some of the symptoms of the disease. Human neurodegenerative diseases are a heterogeneous group of illnesses characterized by progressive loss of neuronal cells and nervous system dysfunction related to several mechanisms such as protein aggregation, neuroinflammation, oxidative stress, and neurotransmission dysfunction. Neuroprotective compounds are essential in the prevention and management of neurodegenerative diseases. This review will focus on the neurodegeneration mechanisms and the compounds (proteins, polyunsaturated fatty acids (PUFAs), polysaccharides, carotenoids, phycobiliproteins, phenolic compounds, among others) present in seaweeds that have shown in vivo and in vitro neuroprotective activity. Additionally, it will cover the recent findings on the neuroprotective effects of bioactive compounds from macroalgae, with a focus on their biological potential and possible mechanism of action, including microbiota modulation. Furthermore, gastrointestinal digestion, absorption, and bioavailability will be discussed. Moreover, the clinical trials using seaweed-based drugs or extracts to treat neurodegenerative disorders will be presented, showing the real potential and limitations that a specific metabolite or extract may have as a new therapeutic agent considering the recent approval of a seaweed-based drug to treat Alzheimer’s disease. |
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| AbstractList | Currently, there is no known cure for neurodegenerative disease. However, the available therapies aim to manage some of the symptoms of the disease. Human neurodegenerative diseases are a heterogeneous group of illnesses characterized by progressive loss of neuronal cells and nervous system dysfunction related to several mechanisms such as protein aggregation, neuroinflammation, oxidative stress, and neurotransmission dysfunction. Neuroprotective compounds are essential in the prevention and management of neurodegenerative diseases. This review will focus on the neurodegeneration mechanisms and the compounds (proteins, polyunsaturated fatty acids (PUFAs), polysaccharides, carotenoids, phycobiliproteins, phenolic compounds, among others) present in seaweeds that have shown in vivo and in vitro neuroprotective activity. Additionally, it will cover the recent findings on the neuroprotective effects of bioactive compounds from macroalgae, with a focus on their biological potential and possible mechanism of action, including microbiota modulation. Furthermore, gastrointestinal digestion, absorption, and bioavailability will be discussed. Moreover, the clinical trials using seaweed-based drugs or extracts to treat neurodegenerative disorders will be presented, showing the real potential and limitations that a specific metabolite or extract may have as a new therapeutic agent considering the recent approval of a seaweed-based drug to treat Alzheimer’s disease. |
| Author | Vieira, Mónica Grosso, Clara Delerue-Matos, Cristina Soares, Cristina Martins, Bruna |
| AuthorAffiliation | 1 LAQV, REQUIMTE, Instituto Superior de Engenharia do Porto, Instituto Politécnico do Porto, Rua Dr. António Bernardino de Almeida 431, 4249-015 Porto, Portugal; brunadaniela99@outlook.pt (B.M.); cmm@isep.ipp.pt (C.D.-M.) 2 Ciências Químicas e das Biomoléculas/CISA, Escola Superior de Saúde, Instituto Politécnico do Porto, Rua Dr. António Bernardino de Almeida 400, 4200-072 Porto, Portugal; mav@ess.ipp.pt |
| AuthorAffiliation_xml | – name: 1 LAQV, REQUIMTE, Instituto Superior de Engenharia do Porto, Instituto Politécnico do Porto, Rua Dr. António Bernardino de Almeida 431, 4249-015 Porto, Portugal; brunadaniela99@outlook.pt (B.M.); cmm@isep.ipp.pt (C.D.-M.) – name: 2 Ciências Químicas e das Biomoléculas/CISA, Escola Superior de Saúde, Instituto Politécnico do Porto, Rua Dr. António Bernardino de Almeida 400, 4200-072 Porto, Portugal; mav@ess.ipp.pt |
| Author_xml | – sequence: 1 givenname: Bruna surname: Martins fullname: Martins, Bruna – sequence: 2 givenname: Mónica orcidid: 0000-0002-8687-4811 surname: Vieira fullname: Vieira, Mónica – sequence: 3 givenname: Cristina orcidid: 0000-0002-3924-776X surname: Delerue-Matos fullname: Delerue-Matos, Cristina – sequence: 4 givenname: Clara surname: Grosso fullname: Grosso, Clara – sequence: 5 givenname: Cristina orcidid: 0000-0003-0924-9681 surname: Soares fullname: Soares, Cristina |
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| CitedBy_id | crossref_primary_10_37349_eaa_2024_00035 crossref_primary_10_3389_fimmu_2023_1273570 crossref_primary_10_1016_j_fbio_2024_103774 crossref_primary_10_3390_cells12222652 crossref_primary_10_3390_cells12222595 crossref_primary_10_3390_bioengineering10070871 crossref_primary_10_1088_1755_1315_1118_1_012028 crossref_primary_10_3390_ph16050712 crossref_primary_10_1016_j_carbpol_2022_120326 crossref_primary_10_1007_s10571_023_01416_7 crossref_primary_10_3390_ph16101355 crossref_primary_10_1016_j_foodres_2024_114646 crossref_primary_10_3390_life13091831 crossref_primary_10_3390_molecules28114285 |
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| Title | Biological Potential, Gastrointestinal Digestion, Absorption, and Bioavailability of Algae-Derived Compounds with Neuroprotective Activity: A Comprehensive Review |
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