Human Airway Smooth Muscle Cells Express the High Affinity Receptor for IgE (FcεRI): A Critical Role of FcεRI in Human Airway Smooth Muscle Cell Function

• Published in: The Journal of immunology (1950) Vol. 175; no. 4; pp. 2613 - 2621
• Main Authors: Gounni, Abdelilah Soussi, Wellemans, Vincent, Yang, Jia, Bellesort, Fabienne, Kassiri, Kamrouz, Gangloff, Sophie, Guenounou, Moncef, Halayko, Andrew J., Hamid, Qutayba, Lamkhioued, Bouchaib
• Format: Journal Article
• Language: English
• Published: United States 15.08.2005
• Subjects: Asthma - immunology; Asthma - metabolism; Asthma - pathology; Bronchi - immunology; Bronchi - metabolism; Bronchi - pathology; Bronchial Hyperreactivity - immunology; Bronchial Hyperreactivity - metabolism; Bronchial Hyperreactivity - pathology; Calcium Signaling - immunology; Cells, Cultured; Chemokines - metabolism; Cross-Linking Reagents - metabolism; Cytokines - metabolism; Humans; Immunoglobulin E - metabolism; Intracellular Fluid - immunology; Intracellular Fluid - metabolism; Muscle Contraction - immunology; Muscle, Smooth - cytology; Muscle, Smooth - immunology; Muscle, Smooth - metabolism; Protein Binding - immunology; Protein Isoforms - biosynthesis; Receptors, IgE - biosynthesis; Receptors, IgE - genetics; Receptors, IgE - metabolism; Receptors, IgE - physiology; RNA, Messenger - biosynthesis; Th2 Cells - immunology; Th2 Cells - metabolism; Trachea - cytology; Trachea - immunology; Trachea - metabolism

Several reports suggest that activated airway smooth muscle (ASM) cells are capable of generating various proinflammatory mediators, including cytokines and chemokines. However, little is known about the mechanism involved in this process. In this regard, we have examined the expression and the role...