Liver albumin synthesis in sepsis in the rat: influence of parenteral nutrition, glutamine and growth hormone

• Published in: Clinical science (1979) Vol. 105; no. 6; pp. 691 - 698
• Main Authors: O'LEARY, Michael J, KOLLT, Michael, FERGUSON, Colin N, COAKLEY, John H, HINDS, Charles J, PREEDY, Victor R, GARLICK, Peter J
• Format: Journal Article
• Language: English
• Published: London Portland Press 01.12.2003
• Subjects: Albumins - biosynthesis; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Animals; Biological and medical sciences; Emergency and intensive care: infection, septic shock; Glutamine - pharmacology; Growth Hormone - pharmacology; Intensive care medicine; Liver - drug effects; Liver - metabolism; Male; Medical sciences; Parenteral Nutrition; Protein Biosynthesis; Rats; Rats, Wistar; Recombinant Proteins - pharmacology; Sepsis - metabolism; Sepsis - therapy; Nutrition; Rat; Septicemia; Liver; Rodentia; Somatotropin hormone; Albumin; Biological activity; Parenteral administration; Infection; Hypoalbuminemia; Metabolic disorder; Vertebrata; Mammalia; Animal; Mechanism of action; Glutamine

The effect of sepsis on liver synthesis of albumin remains controversial, with studies in man suggesting that synthesis increases, whereas in animals increased, decreased and unaltered synthesis have been reported. To reconcile these conflicting data, total and relative albumin synthesis was measure...