Unveiling the multi-target compounds of Rhazya stricta: Discovery and inhibition of novel target genes for the treatment of clear cell renal cell carcinoma

• Published in: Computers in biology and medicine Vol. 165; p. 107424
• Main Authors: Rehman, Abdur, Fatima, Israr, Wang, Yinuo, Tong, Jiapei, Noor, Fatima, Qasim, Muhammad, Peng, Yuzhong, Liao, Mingzhi
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 01.10.2023; Elsevier Limited
• Subjects: Biomarkers; Cancer therapies; Cell division; Clear cell renal cell carcinoma; Clear cell-type renal cell carcinoma; Data collection; Data mining; Datasets; Drug therapy; ErbB-2 protein; Flavonoids; Gelatinase B; Gene expression; Genes; Genomics; In vivo methods and tests; Investigations; Kidney cancer; Kidneys; Kinases; Malignancy; Medical innovations; Medicinal plants; Metabolites; Molecular docking; Molecular dynamic simulation; Molecular modelling; Pharmacokinetics; Pharmacology; Phytochemicals; Proteins; R&D; Research & development; Rhazya stricta; Survival analysis; Therapeutic targets; Tissue analysis; Toxicity; Clear cell renal cell carcinoma; Phytochemicals; Molecular dynamic simulation; Rhazya stricta; Molecular docking

Clear cell renal cell carcinoma (ccRCC) is a prevalent kidney malignancy with a pressing need for innovative therapeutic strategies. In this context, emerging research has focused on exploring the medicinal potential of plants such as Rhazya stricta. Nevertheless, the complex molecular mechanisms un...