Chain Elongation of Linoleic Acid and Its Inhibition by Other Fatty Acids in Vitro
Linoleic acid-1- 14 C was incubated with subcellular fractions of rat liver to study the mechanism of polyunsaturated fatty acid synthesis. The most effective system for the chain elongation of linoleic acid to eicosadienoic acid was liver microsomes plus malonyl coenzyme A with cofactors, NADPH, an...
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| Published in | The Journal of biological chemistry Vol. 242; no. 19; pp. 4507 - 4514 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
American Society for Biochemistry and Molecular Biology
10.10.1967
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Linoleic acid-1- 14 C was incubated with subcellular fractions of rat liver to study the mechanism of polyunsaturated fatty acid synthesis. The
most effective system for the chain elongation of linoleic acid to eicosadienoic acid was liver microsomes plus malonyl coenzyme
A with cofactors, NADPH, and ATP. Under anaerobic conditions, the chain elongation reaction could be separated quantitatively
from the dehydrogenation reaction which otherwise required the same system. The chain elongation of linoleic acid was inhibited
by saturated fatty acids of which myristic and pentadecanoic acids were most effective. Mono-unsaturated and polyunsaturated
fatty acids also act as inhibitors. From consideration of reaction kinetics and inhibition by other fatty acids, the conversion
of linoleic acid to γ-linolenic acid seems preferred over the conversion of linoleic acid to homolinoleic acid. |
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| AbstractList | Linoleic acid-1- 14 C was incubated with subcellular fractions of rat liver to study the mechanism of polyunsaturated fatty acid synthesis. The
most effective system for the chain elongation of linoleic acid to eicosadienoic acid was liver microsomes plus malonyl coenzyme
A with cofactors, NADPH, and ATP. Under anaerobic conditions, the chain elongation reaction could be separated quantitatively
from the dehydrogenation reaction which otherwise required the same system. The chain elongation of linoleic acid was inhibited
by saturated fatty acids of which myristic and pentadecanoic acids were most effective. Mono-unsaturated and polyunsaturated
fatty acids also act as inhibitors. From consideration of reaction kinetics and inhibition by other fatty acids, the conversion
of linoleic acid to γ-linolenic acid seems preferred over the conversion of linoleic acid to homolinoleic acid. |
| Author | Manfred Deubig Kirsten Christiansen Ralph T. Holman Minerva V. Gan Hans Mohrhauer |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/4383633$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1093/jn/81.1.67 10.1021/jo01033a065 10.1007/BF02638432 10.1016/0005-2760(65)90036-6 10.1515/znb-1953-1005 10.1016/S0022-2275(20)39034-9 10.1093/jn/88.1.26 10.1016/S0021-9258(19)63664-1 10.1007/BF02541306 10.1007/BF02633376 10.1016/0005-2760(67)90024-0 10.1016/0003-2697(62)90029-5 10.1016/0006-291X(61)90376-X 10.1093/jn/91.4.521 10.1016/S0021-9258(18)96419-7 10.1016/S0022-2275(20)40395-5 10.1016/0005-2760(66)90024-5 10.1038/194868a0 10.1515/bchm2.1960.320.1.218 10.1515/bchm2.1963.333.1.71 10.1002/jlac.19515740103 10.1016/S0022-2275(20)40341-4 10.1515/bchm2.1964.337.1.123 |
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| References | Mohrhauer (10.1016/S0021-9258(18)99567-0_bib9) 1963; 81 Baumann (10.1016/S0021-9258(18)99567-0_bib23) 1964; 29 Beisenherz (10.1016/S0021-9258(18)99567-0_bib14) 1953; 8B Machlin (10.1016/S0021-9258(18)99567-0_bib29) 1962; 194 Lowry (10.1016/S0021-9258(18)99567-0_bib31) 1966; 88 Nugteren (10.1016/S0021-9258(18)99567-0_bib6) 1963; 89 Siekevitz (10.1016/S0021-9258(18)99567-0_bib12) 1962; 5 Holman (10.1016/S0021-9258(18)99567-0_bib22) 1966; 9 Brenner (10.1016/S0021-9258(18)99567-0_bib20) 1966; 241 Stein (10.1016/S0021-9258(18)99567-0_bib25) 1962; 3 Nugteren (10.1016/S0021-9258(18)99567-0_bib7) 1965; 106 Klenck (10.1016/S0021-9258(18)99567-0_bib2) 1960; 320 Lowry (10.1016/S0021-9258(18)99567-0_bib30) 1966; 116 Stoffel (10.1016/S0021-9258(18)99567-0_bib4) 1963; 333 Dhopeshwarkar (10.1016/S0021-9258(18)99567-0_bib8) 1961; 38 Mohrhauer (10.1016/S0021-9258(18)99567-0_bib10) 1967; 91 Gellhorn (10.1016/S0021-9258(18)99567-0_bib21) 1964; 84 Lynen (10.1016/S0021-9258(18)99567-0_bib28) 1961; 20 Hogeboom (10.1016/S0021-9258(18)99567-0_bib13) 1955; 1 Eggerer (10.1016/S0021-9258(18)99567-0_bib15) 1962; 335 Stoffel (10.1016/S0021-9258(18)99567-0_bib27) 1961; 6 Stadtman (10.1016/S0021-9258(18)99567-0_bib17) 1957; 3 10.1016/S0021-9258(18)99567-0_bib24 Mead (10.1016/S0021-9258(18)99567-0_bib1) 1957; 229 Brenner (10.1016/S0021-9258(18)99567-0_bib32) 1967; 137 Mohrhauer (10.1016/S0021-9258(18)99567-0_bib11) 1963; 4 Dutton (10.1016/S0021-9258(18)99567-0_bib18) 1961; 38 Wakil (10.1016/S0021-9258(18)99567-0_bib3) 1961; 2 Lynen (10.1016/S0021-9258(18)99567-0_bib16) 1951; 374 Stoffel (10.1016/S0021-9258(18)99567-0_bib5) 1964; 337 Mohrhauer (10.1016/S0021-9258(18)99567-0_bib19) 1965; 42 Snyder (10.1016/S0021-9258(18)99567-0_bib26) 1962; 4 |
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| SubjectTerms | Adenosine Triphosphate Animals Chromatography, Gas Coenzyme A Depression, Chemical Fatty Acids - biosynthesis Fatty Acids - pharmacology Hydrogen-Ion Concentration Kinetics Linoleic Acids - metabolism Liver - metabolism Male Microsomes - metabolism Models, Biological NADP Rats Temperature |
| Title | Chain Elongation of Linoleic Acid and Its Inhibition by Other Fatty Acids in Vitro |
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