Tunicamycin Inhibits the Expression of Functional Thrombin Receptors on Human T-Lymphoblastoid Cells

• Published in: Biochemical and biophysical research communications Vol. 206; no. 3; pp. 857 - 862
• Main Authors: Tordai, A., Brass, L.F., Gelfand, E.W.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 26.01.1995
• Subjects: Amino Acid Sequence; Antibodies - pharmacology; Calcium - metabolism; CD3 Complex - immunology; Cell Line; Fluorescent Antibody Technique; Glycosylation; Humans; Molecular Sequence Data; Receptors, Thrombin - metabolism; T-Lymphocytes - drug effects; T-Lymphocytes - metabolism; Thrombin - pharmacology; Tunicamycin - pharmacology

N-linked glycosylation plays an important role in intracellular trafficking and the surface expression of many membrane-associated proteins. In the present report we investigated the effect of tunicamycin, a specific inhibitor of N-linked glycosylation, on the expression and function of the thrombin...